Expression of LNX2 in cancer - Summary - The Human Protein Atlas

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LNX2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LNX2
Gene description	Ligand of numb-protein X 2
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic and membranous expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA040698
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA040698

GENE INFORMATION
Gene name	LNX2 (HGNC Symbol)
Synonyms	MGC46315, PDZRN1
Description	Ligand of numb-protein X 2 (HGNC Symbol)
Entrez gene summary
Chromosome	13
Cytoband	q12.2
Chromosome location (bp)	27545911 - 27620404
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139517 (version 83.38)
Entrez gene	222484
UniProt	Q8N448 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N448
Antibodypedia	LNX2 antibodies

PROTEIN BROWSER

LNX2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LNX2-001 ENSP00000325929 ENST00000316334	Q8N448 [Direct mapping] Ligand of Numb protein X 2 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0030165 [PDZ domain binding] GO:0046872 [metal ion binding] GO:0051260 [protein homooligomerization] Show all	690 aa 76 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.