Expression of CCDC65 in cancer - Summary - The Human Protein Atlas

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CCDC65

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CCDC65
Gene description	Coiled-coil domain containing 65
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Group enriched (fallopian tube, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA038520
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038520

GENE INFORMATION
Gene name	CCDC65 (HGNC Symbol)
Synonyms	CFAP250, CILD27, DRC2, FAP250, FLJ35732, NYD-SP28
Description	Coiled-coil domain containing 65 (HGNC Symbol)
Entrez gene summary	This gene encodes a sperm tail protein that is highly expressed in adult testis, spermatocytes and spermatids. The protein plays a critical role in the assembly of the nexin-dynein regulatory complex. Mutations in this gene result in primary ciliary dyskinesia. [provided by RefSeq, Nov 2013]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	48904110 - 48931840
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139537 (version 83.38)
Entrez gene	85478
UniProt	Q8IXS2 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IXS2
Antibodypedia	CCDC65 antibodies

PROTEIN BROWSER

CCDC65-001	CCDC65-002	CCDC65-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CCDC65-001 ENSP00000312706 ENST00000320516	Q8IXS2 [Direct mapping] Coiled-coil domain-containing protein 65 Show all	Predicted intracellular proteins Disease related genes Show all		484 aa 57.3 kDa	No	0
CCDC65-002 ENSP00000266984 ENST00000266984	Q8IXS2 [Direct mapping] Coiled-coil domain-containing protein 65 Show all	Predicted intracellular proteins Disease related genes Show all		497 aa 58.7 kDa	No	0
CCDC65-005 ENSP00000446569 ENST00000552942	F8VR42 [Direct mapping] Coiled-coil domain-containing protein 65 Show all	Predicted intracellular proteins Show all		373 aa 44 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.