Tissue expression of SLC39A5 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	SLC39A5
Gene description	Solute carrier family 39 (zinc transporter), member 5
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Predicted secreted proteins Transporters
Predicted localization	Membrane,Secreted
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Group enriched (colon, duodenum, kidney, liver, pancreas, rectum, small intestine)
GTEx:	Group enriched (colon, kidney, liver, pancreas, small intestine)
FANTOM5:	Tissue enhanced (colon, pancreas, small intestine)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, duodenum, kidney, liver, pancreas, rectum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Group enriched (colon, kidney, liver, pancreas, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, pancreas, small intestine)

GENE INFORMATION
Gene name	SLC39A5
Synonyms
Description	Solute carrier family 39 (zinc transporter), member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the ZIP family of zinc transporters that transport zinc into cells from outside, and play a crucial role in controlling intracellular zinc levels. Zinc is an essential cofactor for many enzymes and proteins involved in gene transcription, growth, development and differentiation. Mutations in this gene have been associated with autosomal dominant high myopia (MYP24). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	56230049 - 56237846
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139540 (version 83.38)
Entrez gene	283375
UniProt	Q6ZMH5 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZMH5
Antibodypedia	SLC39A5 antibodies

PROTEIN BROWSER

SLC39A5-001	SLC39A5-003	SLC39A5-005	SLC39A5-006	SLC39A5-007	SLC39A5-008	SLC39A5-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC39A5-001 ENSP00000405360 ENST00000454355	Q6ZMH5 [Direct mapping] Zinc transporter ZIP5 A0A024RB24 [Target identity:100%; Query identity:100%] Solute carrier family 39 (Metal ion transporter), member 5, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001654 [eye development] GO:0003674 [molecular_function] GO:0006829 [zinc II ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030001 [metal ion transport] GO:0030509 [BMP signaling pathway] GO:0046873 [metal ion transmembrane transporter activity] GO:0055085 [transmembrane transport] GO:0061351 [neural precursor cell proliferation] GO:0070062 [extracellular exosome] GO:0070315 [G1 to G0 transition involved in cell differentiation] Show all	540 aa 56.5 kDa	Yes	6
SLC39A5-003 ENSP00000266980 ENST00000266980	Q6ZMH5 [Direct mapping] Zinc transporter ZIP5 A0A024RB24 [Target identity:100%; Query identity:100%] Solute carrier family 39 (Metal ion transporter), member 5, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001654 [eye development] GO:0003674 [molecular_function] GO:0006829 [zinc II ion transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0030001 [metal ion transport] GO:0030509 [BMP signaling pathway] GO:0034224 [cellular response to zinc ion starvation] GO:0046873 [metal ion transmembrane transporter activity] GO:0048026 [positive regulation of mRNA splicing, via spliceosome] GO:0055085 [transmembrane transport] GO:0061351 [neural precursor cell proliferation] GO:0070062 [extracellular exosome] GO:0070315 [G1 to G0 transition involved in cell differentiation] Show all	540 aa 56.5 kDa	Yes	6
SLC39A5-005 ENSP00000402891 ENST00000419753	C9JPS5 [Direct mapping] Zinc transporter ZIP5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		156 aa 16.4 kDa	Yes	0
SLC39A5-006 ENSP00000404155 ENST00000424625	C9JIB2 [Direct mapping] Zinc transporter ZIP5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		123 aa 12.8 kDa	Yes	0
SLC39A5-007 ENSP00000414868 ENST00000417965	C9JPS6 [Direct mapping] Zinc transporter ZIP5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 13.5 kDa	Yes	0
SLC39A5-008 ENSP00000391711 ENST00000436633	C9JB28 [Direct mapping] Zinc transporter ZIP5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	239 aa 25 kDa	No	2
SLC39A5-009 ENSP00000407399 ENST00000437277	C9JVC6 [Direct mapping] Zinc transporter ZIP5 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		126 aa 13.1 kDa	Yes	0