Expression of RDH16 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

RDH16

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RDH16
Gene description	Retinol dehydrogenase 16 (all-trans)
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Cell line enhanced (HaCaT, hTCEpi)
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 1 antibody. HPA038518
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038518

GENE INFORMATION
Gene name	RDH16 (HGNC Symbol)
Synonyms	RODH-4, SDR9C8
Description	Retinol dehydrogenase 16 (all-trans) (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q13.3
Chromosome location (bp)	56951431 - 56959374
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139547 (version 83.38)
Entrez gene	8608
UniProt	O75452 (UniProt - Evidence at protein level)
neXtProt	NX_O75452
Antibodypedia	RDH16 antibodies

PROTEIN BROWSER

RDH16-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RDH16-002 ENSP00000381206 ENST00000398138	O75452 [Direct mapping] Retinol dehydrogenase 16 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004745 [retinol dehydrogenase activity] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0009055 [electron carrier activity] GO:0016021 [integral component of membrane] GO:0016491 [oxidoreductase activity] GO:0043231 [intracellular membrane-bounded organelle] GO:0055114 [oxidation-reduction process] Show all	317 aa 35.7 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.