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Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Distinct cytoplasmic staining with a granular pattern was observed in thyroid cancers, malignant lymphomas and in a few malignant melanomas, colorectal, gastric, pancreatic and renal cancers. Malignant cells in general were negative.
GENE INFORMATION
Gene name
ACVRL1 (HGNC Symbol)
Synonyms
ACVRLK1, ALK1, HHT, HHT2, ORW2
Description
Activin A receptor type II-like 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a type I cell-surface receptor for the TGF-beta superfamily of ligands. It shares with other type I receptors a high degree of similarity in serine-threonine kinase subdomains, a glycine- and serine-rich region (called the GS domain) preceding the kinase domain, and a short C-terminal tail. The encoded protein, sometimes termed ALK1, shares similar domain structures with other closely related ALK or activin receptor-like kinase proteins that form a subfamily of receptor serine/threonine kinases. Mutations in this gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2. [provided by RefSeq, Jul 2008]