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NABP2

GENERAL INFORMATION

Gene name

 NABP2

Gene description

 Nucleic acid binding protein 2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA044615
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), cervical cancer (favourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Cervical cancer p<0.001
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA044615

GENE INFORMATION

Gene name

 NABP2 (HGNC Symbol)

Synonyms

 hSSB1, MGC2731, OBFC2B, SOSS-B1, SSB1

Description

 Nucleic acid binding protein 2 (HGNC Symbol)

Entrez gene summary

 Single-stranded DNA (ssDNA)-binding proteins, such as OBFC2B, are ubiquitous and essential for a variety of DNA metabolic processes, including replication, recombination, and detection and repair of damage (Richard et al., 2008 [PubMed 18449195]).[supplied by OMIM, Jun 2008]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56222015 - 56229854

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139579 (version 83.38)

Entrez gene

 79035

UniProt

 Q9BQ15 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BQ15

Antibodypedia

 NABP2 antibodies

PROTEIN BROWSER
NABP2-001
NABP2-002
NABP2-003
NABP2-004
NABP2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NABP2-001
ENSP00000369545
ENST00000380198
Q9BQ15 [Direct mapping]
SOSS complex subunit B1
A0A024RB89 [Target identity:100%; Query identity:100%]
Oligonucleotide/oligosaccharide-binding fold containing 2B, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000724 [double-strand break repair via homologous recombination]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0010212 [response to ionizing radiation]
GO:0070876 [SOSS complex]
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 211 aa
22.3 kDa 		No 0
NABP2-002
ENSP00000267023
ENST00000267023
Q9BQ15 [Direct mapping]
SOSS complex subunit B1
A0A024RB89 [Target identity:100%; Query identity:100%]
Oligonucleotide/oligosaccharide-binding fold containing 2B, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0010212 [response to ionizing radiation]
GO:0070876 [SOSS complex]
Show all
 211 aa
22.3 kDa 		No 0
NABP2-003
ENSP00000368862
ENST00000341463
Q9BQ15 [Direct mapping]
SOSS complex subunit B1
A0A024RB89 [Target identity:100%; Query identity:100%]
Oligonucleotide/oligosaccharide-binding fold containing 2B, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003676 [nucleic acid binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007093 [mitotic cell cycle checkpoint]
GO:0010212 [response to ionizing radiation]
GO:0070876 [SOSS complex]
Show all
 211 aa
22.3 kDa 		No 0
NABP2-004
ENSP00000413902
ENST00000447747
C9JT95 [Direct mapping]
SOSS complex subunit B1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
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 144 aa
15.6 kDa 		No 0
NABP2-005
ENSP00000408616
ENST00000399713
C9JMP5 [Direct mapping]
SOSS complex subunit B1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003676 [nucleic acid binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
Show all
 152 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.