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SMARCC2

GENERAL INFORMATION

Gene name

 SMARCC2

Gene description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA021213 , CAB004321
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA021213
CAB004321

GENE INFORMATION

Gene name

 SMARCC2 (HGNC Symbol)

Synonyms

 BAF170, CRACC2, Rsc8

Description

 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and contains a predicted leucine zipper motif typical of many transcription factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 56162983 - 56189567

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000139613 (version 83.38)

Entrez gene

 6601

UniProt

 Q8TAQ2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8TAQ2

Antibodypedia

 SMARCC2 antibodies

PROTEIN BROWSER
SMARCC2-001
SMARCC2-002
SMARCC2-003
SMARCC2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SMARCC2-001
ENSP00000267064
ENST00000267064
Q8TAQ2 [Direct mapping]
SWI/SNF complex subunit SMARCC2
A0A024RB22 [Target identity:100%; Query identity:100%]
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2, isoform CRA_a
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016514 [SWI/SNF complex]
GO:0017053 [transcriptional repressor complex]
GO:0021882 [regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment]
GO:0031492 [nucleosomal DNA binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
GO:0090544 [BAF-type complex]
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 1214 aa
132.9 kDa 		No 0
SMARCC2-002
ENSP00000302919
ENST00000347471
Q8TAQ2 [Direct mapping]
SWI/SNF complex subunit SMARCC2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016514 [SWI/SNF complex]
GO:0017053 [transcriptional repressor complex]
GO:0031492 [nucleosomal DNA binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
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 1130 aa
124.8 kDa 		No 0
SMARCC2-003
ENSP00000377591
ENST00000394023
Q8TAQ2 [Direct mapping]
SWI/SNF complex subunit SMARCC2
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000790 [nuclear chromatin]
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0003677 [DNA binding]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006325 [chromatin organization]
GO:0006337 [nucleosome disassembly]
GO:0006338 [chromatin remodeling]
GO:0006351 [transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016514 [SWI/SNF complex]
GO:0017053 [transcriptional repressor complex]
GO:0031492 [nucleosomal DNA binding]
GO:0043044 [ATP-dependent chromatin remodeling]
GO:0043234 [protein complex]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0071564 [npBAF complex]
GO:0071565 [nBAF complex]
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 1152 aa
126.9 kDa 		No 0
SMARCC2-006
ENSP00000449396
ENST00000550164
F8VXC8 [Direct mapping]
SWI/SNF complex subunit SMARCC2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0006338 [chromatin remodeling]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0090544 [BAF-type complex]
Show all
 1245 aa
136.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.