Expression of KANSL2 in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

KANSL2

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KANSL2
Gene description	KAT8 regulatory NSL complex subunit 2
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA038497 , HPA038498
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable) and liver cancer (unfavourable).
Urothelial cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA038497	HPA038498

GENE INFORMATION
Gene name	KANSL2 (HGNC Symbol)
Synonyms	C12orf41, FLJ20436, NSL2
Description	KAT8 regulatory NSL complex subunit 2 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q13.11
Chromosome location (bp)	48653401 - 48682238
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139620 (version 83.38)
Entrez gene	54934
UniProt	Q9H9L4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H9L4
Antibodypedia	KANSL2 antibodies

PROTEIN BROWSER

KANSL2-001	KANSL2-002	KANSL2-005	KANSL2-007	KANSL2-008	KANSL2-009	KANSL2-011

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KANSL2-001 ENSP00000449747 ENST00000550347	F8VX10 [Direct mapping] KAT8 regulatory NSL complex subunit 2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] Show all	675 aa 74.7 kDa	Yes	0
KANSL2-002 ENSP00000415436 ENST00000420613	Q9H9L4 [Direct mapping] KAT8 regulatory NSL complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0043981 [histone H4-K5 acetylation] GO:0043982 [histone H4-K8 acetylation] GO:0043984 [histone H4-K16 acetylation] GO:0043995 [histone acetyltransferase activity (H4-K5 specific)] GO:0043996 [histone acetyltransferase activity (H4-K8 specific)] GO:0044545 [NSL complex] GO:0046972 [histone acetyltransferase activity (H4-K16 specific)] Show all	492 aa 55 kDa	No	0
KANSL2-005 ENSP00000448833 ENST00000553086	F8VXI8 [Direct mapping] KAT8 regulatory NSL complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] Show all	454 aa 51 kDa	No	0
KANSL2-007 ENSP00000447608 ENST00000547087	H0YHR2 [Direct mapping] KAT8 regulatory NSL complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] Show all	206 aa 22.9 kDa	No	0
KANSL2-008 ENSP00000448473 ENST00000550870	F8VRX7 [Direct mapping] KAT8 regulatory NSL complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] Show all	108 aa 12.3 kDa	No	0
KANSL2-009 ENSP00000448129 ENST00000550931	F8VUX5 [Direct mapping] KAT8 regulatory NSL complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] Show all	133 aa 14.8 kDa	No	0
KANSL2-011 ENSP00000446493 ENST00000548304	F8VP38 [Direct mapping] KAT8 regulatory NSL complex subunit 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000123 [histone acetyltransferase complex] Show all	69 aa 8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.