Expression of MAP3K12 in cancer - Summary - The Human Protein Atlas

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MAP3K12

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP3K12
Gene description	Mitogen-activated protein kinase kinase kinase 12
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA039936
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039936

GENE INFORMATION
Gene name	MAP3K12 (HGNC Symbol)
Synonyms	DLK, MEKK12, MUK, ZPK, ZPKP1
Description	Mitogen-activated protein kinase kinase kinase 12 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.[provided by RefSeq, Jul 2010]
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	53479669 - 53500063
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139625 (version 83.38)
Entrez gene	7786
UniProt	Q12852 (UniProt - Evidence at protein level)
neXtProt	NX_Q12852
Antibodypedia	MAP3K12 antibodies

PROTEIN BROWSER

MAP3K12-002	MAP3K12-004	MAP3K12-005	MAP3K12-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP3K12-002 ENSP00000449038 ENST00000547488	Q12852 [Direct mapping] Mitogen-activated protein kinase kinase kinase 12 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0016020 [membrane] GO:0016572 [histone phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019901 [protein kinase binding] GO:0035556 [intracellular signal transduction] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	892 aa 96.3 kDa	No	0
MAP3K12-004 ENSP00000267079 ENST00000267079	Q12852 [Direct mapping] Mitogen-activated protein kinase kinase kinase 12 A0A024RAY5 [Target identity:100%; Query identity:100%] Mitogen-activated protein kinase kinase kinase 12 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0016020 [membrane] GO:0016572 [histone phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019901 [protein kinase binding] GO:0035556 [intracellular signal transduction] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0098779 [mitophagy in response to mitochondrial depolarization] Show all	859 aa 93.2 kDa	No	0
MAP3K12-005 ENSP00000448689 ENST00000547035	Q12852 [Direct mapping] Mitogen-activated protein kinase kinase kinase 12 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000186 [activation of MAPKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0004709 [MAP kinase kinase kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005886 [plasma membrane] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0016020 [membrane] GO:0016572 [histone phosphorylation] GO:0018105 [peptidyl-serine phosphorylation] GO:0018107 [peptidyl-threonine phosphorylation] GO:0019901 [protein kinase binding] GO:0030424 [axon] GO:0030426 [growth cone] GO:0035556 [intracellular signal transduction] GO:0042803 [protein homodimerization activity] GO:0046777 [protein autophosphorylation] GO:0098779 [mitophagy in response to mitochondrial depolarization] GO:2000672 [negative regulation of motor neuron apoptotic process] Show all	892 aa 96.3 kDa	No	0
MAP3K12-007 ENSP00000454355 ENST00000548565	H3BMF0 [Direct mapping] Mitogen-activated protein kinase kinase kinase 12 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		25 aa 2.6 kDa	No	0

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The Human Protein Atlas

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