Expression of CBLN3 in cancer - Summary - The Human Protein Atlas

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CBLN3

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CBLN3
Gene description	Cerebellin 3 precursor
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, Karpas-707)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic and nuclear expression in CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	External characterization data supports antibody staining but no internal RNA data available for correlation.
Reliability score	Supported based on 1 antibody. HPA041266
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041266

GENE INFORMATION
Gene name	CBLN3
Synonyms
Description	Cerebellin 3 precursor (HGNC Symbol)
Entrez gene summary	Members of the precerebellin family, such as CBLN3, contain a cerebellin motif (see CBLN1; MIM 600432) and a C-terminal C1q signature domain (see MIM 120550) that mediates trimeric assembly of atypical collagen complexes. However, precerebellins do not contain a collagen motif, suggesting that they are not conventional components of the extracellular matrix (Pang et al., 2000 [PubMed 10964938]).[supplied by OMIM, Aug 2009]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24426532 - 24430954
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139899 (version 83.38)
Entrez gene	643866
UniProt	Q6UW01 (UniProt - Evidence at protein level)
neXtProt	NX_Q6UW01
Antibodypedia	CBLN3 antibodies

PROTEIN BROWSER

CBLN3-001	CBLN3-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CBLN3-001 ENSP00000267406 ENST00000267406	Q6UW01 [Direct mapping] Cerebellin-3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0005515 [protein binding] GO:0005615 [extracellular space] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0030054 [cell junction] GO:0045202 [synapse] Show all	205 aa 21.5 kDa	Yes	0
CBLN3-002 ENSP00000450935 ENST00000555436	G3V2Y8 [Direct mapping] Cerebellin-3; HCG40197 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	154 aa 16.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.