Cell atlas - TSSK4 - The Human Protein Atlas

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TSSK4

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cell Junctions

Human cell
	Plasma Membrane

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GENERAL INFORMATION
Gene name	TSSK4
Gene description	Testis-specific serine kinase 4
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cell junctions.
RNA cell category	Mixed
Protein evidence	Evidence at protein level
Main location	Localized to the Cell Junctions (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA060660
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cell junctions.

Main location

Cell Junctions (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA060660	HaCaT	Cell Junctions
	HPA060660	RT4	No staining
	HPA060660	U-2 OS	Cell Junctions

GENE INFORMATION
Gene name	TSSK4 (HGNC Symbol)
Synonyms	C14orf20, STK22E
Description	Testis-specific serine kinase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	24205697 - 24208362
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139908 (version 83.38)
Entrez gene	283629
UniProt	Q6SA08 (UniProt - Evidence at protein level)
neXtProt	NX_Q6SA08
Antibodypedia	TSSK4 antibodies

PROTEIN BROWSER

TSSK4-001	TSSK4-002	TSSK4-003	TSSK4-005	TSSK4-006	TSSK4-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TSSK4-001 ENSP00000287913 ENST00000287913	Q6SA08 [Direct mapping] Testis-specific serine/threonine-protein kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0035556 [intracellular signal transduction] Show all	328 aa 37.5 kDa	No	1
TSSK4-002 ENSP00000339179 ENST00000339917	Q6SA08 [Direct mapping] Testis-specific serine/threonine-protein kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0035556 [intracellular signal transduction] Show all	338 aa 38.4 kDa	No	1
TSSK4-003 ENSP00000452054 ENST00000556621	Q6SA08 [Direct mapping] Testis-specific serine/threonine-protein kinase 4 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0000287 [magnesium ion binding] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007275 [multicellular organismal development] GO:0007283 [spermatogenesis] GO:0030154 [cell differentiation] GO:0032793 [positive regulation of CREB transcription factor activity] GO:0035556 [intracellular signal transduction] Show all	252 aa 29 kDa	No	1
TSSK4-005 ENSP00000450752 ENST00000553766	H0YJ36 [Direct mapping] Testis-specific serine/threonine-protein kinase 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	108 aa 12.2 kDa	No	1
TSSK4-006 ENSP00000412180 ENST00000428351	H7C3J1 [Direct mapping] Testis-specific serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	135 aa 15.4 kDa	No	0
TSSK4-007 ENSP00000451121 ENST00000555092	H0YJB1 [Direct mapping] Testis-specific serine/threonine-protein kinase 4 Show all	Predicted intracellular proteins Show all	GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0035556 [intracellular signal transduction] Show all	143 aa 16.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.