Tissue expression of NOVA1 - Summary - The Human Protein Atlas

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NOVA1

TISSUE

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CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	NOVA1
Gene description	Neuro-oncological ventral antigen 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (cerebellum)
FANTOM5:	Tissue enhanced (cerebellum)

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic and nuclear expression in most tissues.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA004155
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

N/A

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum)

GENE INFORMATION
Gene name	NOVA1
Synonyms
Description	Neuro-oncological ventral antigen 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a neuron-specific RNA-binding protein, a member of the Nova family of paraneoplastic disease antigens, that is recognized and inhibited by paraneoplastic antibodies. These antibodies are found in the sera of patients with paraneoplastic opsoclonus-ataxia, breast cancer, and small cell lung cancer. Alternatively spliced transcripts encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	14
Cytoband	q12
Chromosome location (bp)	26443093 - 26597754
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139910 (version 83.38)
Entrez gene	4857
UniProt	P51513 (UniProt - Evidence at protein level)
neXtProt	NX_P51513
Antibodypedia	NOVA1 antibodies

PROTEIN BROWSER

NOVA1-001	NOVA1-002	NOVA1-003	NOVA1-006	NOVA1-007	NOVA1-008	NOVA1-010	NOVA1-012	NOVA1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOVA1-001 ENSP00000342387 ENST00000344429	P51513 [Direct mapping] RNA-binding protein Nova-1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006396 [RNA processing] GO:0007268 [synaptic transmission] GO:0007626 [locomotory behavior] GO:0008380 [RNA splicing] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] Show all	181 aa 19.5 kDa	No	0
NOVA1-002 ENSP00000447391 ENST00000465357	P51513 [Direct mapping] RNA-binding protein Nova-1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006396 [RNA processing] GO:0007268 [synaptic transmission] GO:0007626 [locomotory behavior] GO:0008380 [RNA splicing] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] Show all	483 aa 49.3 kDa	No	0
NOVA1-003 ENSP00000438875 ENST00000539517	P51513 [Direct mapping] RNA-binding protein Nova-1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000398 [mRNA splicing, via spliceosome] GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0005634 [nucleus] GO:0005730 [nucleolus] GO:0006396 [RNA processing] GO:0007268 [synaptic transmission] GO:0007626 [locomotory behavior] GO:0008380 [RNA splicing] GO:0021510 [spinal cord development] GO:0043231 [intracellular membrane-bounded organelle] GO:0044822 [poly(A) RNA binding] GO:0050684 [regulation of mRNA processing] GO:0051252 [regulation of RNA metabolic process] Show all	507 aa 51.7 kDa	No	0
NOVA1-006 ENSP00000449185 ENST00000549571	F8VWX1 [Direct mapping] RNA-binding protein Nova-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	173 aa 18.6 kDa	No	0
NOVA1-007 ENSP00000408914 ENST00000449198	J3KQU3 [Direct mapping] RNA-binding protein Nova-1 Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	277 aa 28.9 kDa	No	0
NOVA1-008 ENSP00000449113 ENST00000549146	F8VW64 [Direct mapping] RNA-binding protein Nova-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] Show all	96 aa 10.1 kDa	No	0
NOVA1-010 ENSP00000448157 ENST00000547619	F8W659 [Direct mapping] RNA-binding protein Nova-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	211 aa 22.9 kDa	No	0
NOVA1-012 ENSP00000299472 ENST00000347476	G8JLA5 [Direct mapping] RNA-binding protein Nova-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	109 aa 11.8 kDa	No	0
NOVA1-013 ENSP00000459545 ENST00000574031	I3L2B5 [Direct mapping] RNA-binding protein Nova-1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003676 [nucleic acid binding] GO:0003723 [RNA binding] Show all	152 aa 16.3 kDa	No	0

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The Human Protein Atlas

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