Expression of MDGA2 in cancer - Summary - The Human Protein Atlas

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MDGA2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MDGA2
Gene description	MAM domain containing glycosylphosphatidylinositol anchor 2
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (melanoma)
HPA (cell line):	Cell line enhanced (AF22, T-47d, U-138 MG, U-2 OS, WM-115)
HPA (normal tissue):	Group enriched (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression, mainly in Leydig cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA003084
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (melanoma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA003084

GENE INFORMATION
Gene name	MDGA2 (HGNC Symbol)
Synonyms	MAMDC1
Description	MAM domain containing glycosylphosphatidylinositol anchor 2 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q21.3
Chromosome location (bp)	46839629 - 47674954
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139915 (version 83.38)
Entrez gene	161357
UniProt	Q7Z553 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z553
Antibodypedia	MDGA2 antibodies

PROTEIN BROWSER

MDGA2-001	MDGA2-002	MDGA2-005	MDGA2-007	MDGA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MDGA2-001 ENSP00000382178 ENST00000399232	Q7Z553 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007389 [pattern specification process] GO:0016020 [membrane] GO:0021522 [spinal cord motor neuron differentiation] GO:0031225 [anchored component of membrane] Show all	956 aa 107.4 kDa	Yes	1
MDGA2-002 ENSP00000349925 ENST00000357362	Q7Z553 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016020 [membrane] GO:0021522 [spinal cord motor neuron differentiation] GO:0031225 [anchored component of membrane] Show all	727 aa 81.4 kDa	No	1
MDGA2-005 ENSP00000452515 ENST00000486952	G3V5U0 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	142 aa 15.8 kDa	No	0
MDGA2-007 ENSP00000450827 ENST00000554762	H0YJ52 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 2 Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	253 aa 27.6 kDa	No	0
MDGA2-201 ENSP00000405456 ENST00000426342	A0A0A0MSW6 [Direct mapping] MAM domain-containing glycosylphosphatidylinositol anchor protein 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	826 aa 92.8 kDa	No	1

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.