Expression of SLC38A6 in cancer - Summary - The Human Protein Atlas

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SLC38A6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC38A6
Gene description	Solute carrier family 38, member 6
Protein class	Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA018508
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018508

GENE INFORMATION
Gene name	SLC38A6 (HGNC Symbol)
Synonyms	NAT-1
Description	Solute carrier family 38, member 6 (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q23.1
Chromosome location (bp)	60981114 - 61083733
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000139974 (version 83.38)
Entrez gene	145389
UniProt	Q8IZM9 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IZM9
Antibodypedia	SLC38A6 antibodies

PROTEIN BROWSER

SLC38A6-001	SLC38A6-003	SLC38A6-008	SLC38A6-011	SLC38A6-013	SLC38A6-014	SLC38A6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC38A6-001 ENSP00000267488 ENST00000267488	Q8IZM9 [Direct mapping] Probable sodium-coupled neutral amino acid transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0015171 [amino acid transmembrane transporter activity] Show all	456 aa 50.9 kDa	No	>9
SLC38A6-003 ENSP00000395851 ENST00000451406	A0A0C4DG39 [Direct mapping] Probable sodium-coupled neutral amino acid transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	516 aa 57.3 kDa	No	>9
SLC38A6-008 ENSP00000482800 ENST00000534758	A0A087WZP5 [Direct mapping] Probable sodium-coupled neutral amino acid transporter 6 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	42 aa 4.4 kDa	No	0
SLC38A6-011 ENSP00000451244 ENST00000526105	G3V3H5 [Direct mapping] Probable sodium-coupled neutral amino acid transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	127 aa 13.6 kDa	No	3
SLC38A6-013 ENSP00000434543 ENST00000533744	H0YDY0 [Direct mapping] Probable sodium-coupled neutral amino acid transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	195 aa 21.5 kDa	No	4
SLC38A6-014 ENSP00000437190 ENST00000529212	H0YF42 [Direct mapping] Probable sodium-coupled neutral amino acid transporter 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 6TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015171 [amino acid transmembrane transporter activity] Show all	229 aa 26.1 kDa	No	6
SLC38A6-201 ENSP00000346959 ENST00000354886	Q8IZM9 [Direct mapping] Probable sodium-coupled neutral amino acid transporter 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006814 [sodium ion transport] GO:0015171 [amino acid transmembrane transporter activity] Show all	521 aa 57.9 kDa	No	>9

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The Human Protein Atlas

The Human Protein Atlas project is funded
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