Expression of PTGR2 in cancer - Summary - The Human Protein Atlas

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PTGR2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PTGR2
Gene description	Prostaglandin reductase 2
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (T-47d)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA001125
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001125

GENE INFORMATION
Gene name	PTGR2 (HGNC Symbol)
Synonyms	FLJ39091, ZADH1
Description	Prostaglandin reductase 2 (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme involved in the metabolism of prostaglandins. The encoded protein catalyzes the NADPH-dependent conversion of 15-keto-prostaglandin E2 to 15-keto-13,14-dihydro-prostaglandin E2. This protein may also be involved in regulating activation of the peroxisome proliferator-activated receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	73851844 - 73886827
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140043 (version 83.38)
Entrez gene	145482
UniProt	Q8N8N7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N8N7
Antibodypedia	PTGR2 antibodies

PROTEIN BROWSER

PTGR2-001	PTGR2-003	PTGR2-004	PTGR2-008

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PTGR2-001 ENSP00000452280 ENST00000555661	Q8N8N7 [Direct mapping] Prostaglandin reductase 2 V9HW32 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 298; Zinc binding alcohol dehydrogenase, domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0005737 [cytoplasm] GO:0006693 [prostaglandin metabolic process] GO:0036132 [13-prostaglandin reductase activity] GO:0047522 [15-oxoprostaglandin 13-oxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	351 aa 38.5 kDa	No	0
PTGR2-003 ENSP00000267568 ENST00000267568	Q8N8N7 [Direct mapping] Prostaglandin reductase 2 V9HW32 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 298; Zinc binding alcohol dehydrogenase, domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006693 [prostaglandin metabolic process] GO:0036132 [13-prostaglandin reductase activity] GO:0047522 [15-oxoprostaglandin 13-oxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	351 aa 38.5 kDa	No	0
PTGR2-004 ENSP00000450975 ENST00000555228	Q8N8N7 [Direct mapping] Prostaglandin reductase 2 V9HW32 [Target identity:100%; Query identity:100%] Epididymis secretory protein Li 298; Zinc binding alcohol dehydrogenase, domain containing 1, isoform CRA_a Show all	Enzymes ENZYME proteins Oxidoreductases MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005737 [cytoplasm] GO:0006693 [prostaglandin metabolic process] GO:0036132 [13-prostaglandin reductase activity] GO:0047522 [15-oxoprostaglandin 13-oxidase activity] GO:0055114 [oxidation-reduction process] GO:0070062 [extracellular exosome] Show all	351 aa 38.5 kDa	No	0
PTGR2-008 ENSP00000450824 ENST00000553813	G3V2R9 [Direct mapping] Prostaglandin reductase 2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0008270 [zinc ion binding] GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	217 aa 23.4 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.