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AK7

GENERAL INFORMATION

Gene name

 AK7

Gene description

 Adenylate kinase 7

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (BEWO, MCF7, REH)
HPA (normal tissue):Tissue enhanced (fallopian tube)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA003543
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (favourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA003543

GENE INFORMATION

Gene name

 AK7 (HGNC Symbol)

Synonyms

 FLJ32864

Description

 Adenylate kinase 7 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q32.2

Chromosome location (bp)

 96392111 - 96489427

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140057 (version 83.38)

Entrez gene

 122481

UniProt

 Q96M32 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96M32

Antibodypedia

 AK7 antibodies

PROTEIN BROWSER
AK7-001
AK7-002
AK7-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
AK7-001
ENSP00000267584
ENST00000267584
Q96M32 [Direct mapping]
Adenylate kinase 7
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0002437 [inflammatory response to antigenic stimulus]
GO:0003351 [epithelial cilium movement]
GO:0004017 [adenylate kinase activity]
GO:0004127 [cytidylate kinase activity]
GO:0004550 [nucleoside diphosphate kinase activity]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006165 [nucleoside diphosphate phosphorylation]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0009142 [nucleoside triphosphate biosynthetic process]
GO:0015949 [nucleobase-containing small molecule interconversion]
GO:0035082 [axoneme assembly]
GO:0044281 [small molecule metabolic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
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 723 aa
82.7 kDa 		No 0
AK7-002
ENSP00000451068
ENST00000555570
G3V365 [Direct mapping]
Adenylate kinase 7; Adenylate kinase 7, isoform CRA_e
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Predicted intracellular proteins
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GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
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 107 aa
11.6 kDa 		No 0
AK7-005
ENSP00000450453
ENST00000554706
H0YIY5 [Direct mapping]
Adenylate kinase 7
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Predicted intracellular proteins
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GO:0005524 [ATP binding]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0016310 [phosphorylation]
GO:0019205 [nucleobase-containing compound kinase activity]
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 152 aa
17.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.