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SLC24A4

GENERAL INFORMATION

Gene name

 SLC24A4

Gene description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (glioma, melanoma)
HPA (cell line):Cell line enhanced (SCLC-21H)
HPA (normal tissue):Tissue enhanced (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (glioma, melanoma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 SLC24A4 (HGNC Symbol)

Synonyms

 NCKX4

Description

 Solute carrier family 24 (sodium/potassium/calcium exchanger), member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

Chromosome

 14

Cytoband

 q32.12

Chromosome location (bp)

 92322581 - 92501483

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140090 (version 83.38)

Entrez gene

 123041

UniProt

 Q8NFF2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFF2

Antibodypedia

 SLC24A4 antibodies

PROTEIN BROWSER
SLC24A4-001
SLC24A4-002
SLC24A4-003
SLC24A4-007
SLC24A4-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC24A4-001
ENSP00000431840
ENST00000532405
Q8NFF2 [Direct mapping]
Sodium/potassium/calcium exchanger 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007608 [sensory perception of smell]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0097186 [amelogenesis]
Show all
 622 aa
69 kDa 		No >9
SLC24A4-002
ENSP00000433302
ENST00000531433
Q8NFF2 [Direct mapping]
Sodium/potassium/calcium exchanger 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007608 [sensory perception of smell]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0097186 [amelogenesis]
Show all
 603 aa
67 kDa 		No >9
SLC24A4-003
ENSP00000376948
ENST00000393265
Q8NFF2 [Direct mapping]
Sodium/potassium/calcium exchanger 4
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0005262 [calcium channel activity]
GO:0005509 [calcium ion binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006811 [ion transport]
GO:0006813 [potassium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0007608 [sensory perception of smell]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0015293 [symporter activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030955 [potassium ion binding]
GO:0031402 [sodium ion binding]
GO:0035725 [sodium ion transmembrane transport]
GO:0050896 [response to stimulus]
GO:0055085 [transmembrane transport]
GO:0070588 [calcium ion transmembrane transport]
GO:0097186 [amelogenesis]
Show all
 558 aa
61.9 kDa 		No >9
SLC24A4-007
ENSP00000432464
ENST00000525557
H0YCX3 [Direct mapping]
Sodium/potassium/calcium exchanger 4
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Show all
GO:0005887 [integral component of plasma membrane]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
Show all
 464 aa
51.1 kDa 		No 8
SLC24A4-009
ENSP00000452099
ENST00000554461
G3V505 [Direct mapping]
Sodium/potassium/calcium exchanger 4
Show all
   MEMSAT3 predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Show all
GO:0005887 [integral component of plasma membrane]
GO:0008273 [calcium, potassium:sodium antiporter activity]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
GO:0055085 [transmembrane transport]
Show all
 64 aa
6.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.