Expression of NIPA2 in cancer - Summary - The Human Protein Atlas

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NIPA2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NIPA2
Gene description	Non imprinted in Prader-Willi/Angelman syndrome 2
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA067160
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA067160

GENE INFORMATION
Gene name	NIPA2
Synonyms
Description	Non imprinted in Prader-Willi/Angelman syndrome 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]
Chromosome	15
Cytoband	q11.2
Chromosome location (bp)	22838641 - 22868384
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140157 (version 83.38)
Entrez gene	81614
UniProt	Q8N8Q9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N8Q9
Antibodypedia	NIPA2 antibodies

PROTEIN BROWSER

NIPA2-001	NIPA2-002	NIPA2-003	NIPA2-004	NIPA2-009	NIPA2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NIPA2-001 ENSP00000337618 ENST00000337451	Q8N8Q9 [Direct mapping] Magnesium transporter NIPA2 A0A024R372 [Target identity:100%; Query identity:100%] Non imprinted in Prader-Willi/Angelman syndrome 2, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	360 aa 39.2 kDa	No	9
NIPA2-002 ENSP00000352762 ENST00000359727	Q8N8Q9 [Direct mapping] Magnesium transporter NIPA2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	341 aa 37 kDa	No	8
NIPA2-003 ENSP00000381095 ENST00000398013	Q8N8Q9 [Direct mapping] Magnesium transporter NIPA2 A0A024R372 [Target identity:100%; Query identity:100%] Non imprinted in Prader-Willi/Angelman syndrome 2, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	360 aa 39.2 kDa	No	9
NIPA2-004 ENSP00000437746 ENST00000539711	Q8N8Q9 [Direct mapping] Magnesium transporter NIPA2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	341 aa 37 kDa	No	8
NIPA2-009 ENSP00000453700 ENST00000560039	H0YMQ7 [Direct mapping] Magnesium transporter NIPA2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	59 aa 6.5 kDa	No	1
NIPA2-201 ENSP00000381096 ENST00000398014	Q8N8Q9 [Direct mapping] Magnesium transporter NIPA2 A0A024R372 [Target identity:100%; Query identity:100%] Non imprinted in Prader-Willi/Angelman syndrome 2, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005769 [early endosome] GO:0005886 [plasma membrane] GO:0015095 [magnesium ion transmembrane transporter activity] GO:0015693 [magnesium ion transport] GO:0016021 [integral component of membrane] GO:1903830 [magnesium ion transmembrane transport] Show all	360 aa 39.2 kDa	No	9

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