Expression of SLC12A6 in cancer - Summary - The Human Protein Atlas

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SLC12A6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC12A6
Gene description	Solute carrier family 12 (potassium/chloride transporter), member 6
Protein class	Disease related genes Potential drug targets Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HaCaT)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Caution, Splice and/or transcript discrepancy exists. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA034563
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA034563

GENE INFORMATION
Gene name	SLC12A6 (HGNC Symbol)
Synonyms	ACCPN, KCC3
Description	Solute carrier family 12 (potassium/chloride transporter), member 6 (HGNC Symbol)
Entrez gene summary	This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q14
Chromosome location (bp)	34229996 - 34338060
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140199 (version 83.38)
Entrez gene	9990
UniProt	Q9UHW9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHW9
Antibodypedia	SLC12A6 antibodies

PROTEIN BROWSER

SLC12A6-001	SLC12A6-002	SLC12A6-003	SLC12A6-004	SLC12A6-006	SLC12A6-008	SLC12A6-009	SLC12A6-010	SLC12A6-011	SLC12A6-012	SLC12A6-013	SLC12A6-017	SLC12A6-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC12A6-001 ENSP00000290209 ENST00000290209	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1099 aa 122.1 kDa	No	>9
SLC12A6-002 ENSP00000380819 ENST00000397707	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1135 aa 126 kDa	No	>9
SLC12A6-003 ENSP00000346112 ENST00000354181	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 A0A024R9I5 [Target identity:100%; Query identity:100%] Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_d Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1150 aa 127.6 kDa	No	>9
SLC12A6-004 ENSP00000452776 ENST00000558589	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1141 aa 126.6 kDa	No	>9
SLC12A6-006 ENSP00000387725 ENST00000458406	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 A0A024R9K8 [Target identity:100%; Query identity:100%] Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1091 aa 121.1 kDa	No	>9
SLC12A6-008 ENSP00000380814 ENST00000397702	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 A0A024R9K8 [Target identity:100%; Query identity:100%] Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1091 aa 121.1 kDa	No	>9
SLC12A6-009 ENSP00000453473 ENST00000558667	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 A0A024R9I5 [Target identity:100%; Query identity:100%] Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_d Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1150 aa 127.6 kDa	No	>9
SLC12A6-010 ENSP00000454168 ENST00000560611	Q9UHW9 [Direct mapping] Solute carrier family 12 member 6 A0A024R9I5 [Target identity:100%; Query identity:100%] Solute carrier family 12 (Potassium/chloride transporters), member 6, isoform CRA_d Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0005215 [transporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0006884 [cell volume homeostasis] GO:0010107 [potassium ion import] GO:0015079 [potassium ion transmembrane transporter activity] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016323 [basolateral plasma membrane] GO:0019901 [protein kinase binding] GO:0022820 [potassium ion symporter activity] GO:0035826 [rubidium ion transport] GO:0035827 [rubidium ion transmembrane transporter activity] GO:0055064 [chloride ion homeostasis] GO:0055075 [potassium ion homeostasis] GO:0055085 [transmembrane transport] GO:0071476 [cellular hypotonic response] GO:0071477 [cellular hypotonic salinity response] GO:0071805 [potassium ion transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	1150 aa 127.6 kDa	No	>9
SLC12A6-011 ENSP00000452828 ENST00000559236	H0YKJ2 [Direct mapping] Solute carrier family 12 member 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		135 aa 14.8 kDa	No	0
SLC12A6-012 ENSP00000452771 ENST00000561120	H0YKE6 [Direct mapping] Solute carrier family 12 member 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.9 kDa	No	0
SLC12A6-013 ENSP00000452857 ENST00000559484	H0YKL8 [Direct mapping] Solute carrier family 12 member 6 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		61 aa 6.6 kDa	No	0
SLC12A6-017 ENSP00000452705 ENST00000560164	B3KXX3 [Direct mapping] Solute carrier family 12 member 6; cDNA FLJ46254 fis, clone TESTI4023096, highly similar to Solute carrier family 12 member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0006811 [ion transport] GO:0015377 [cation:chloride symporter activity] GO:0015379 [potassium:chloride symporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] Show all	962 aa 106.9 kDa	No	>9
SLC12A6-018 ENSP00000454037 ENST00000560332	H0YNJ5 [Direct mapping] Solute carrier family 12 member 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	107 aa 11.6 kDa	No	2

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The Human Protein Atlas

The Human Protein Atlas project is funded
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