Expression of DUOXA1 in cancer - Summary - The Human Protein Atlas

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DUOXA1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DUOXA1
Gene description	Dual oxidase maturation factor 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (thyroid cancer)
HPA (cell line):	Cell line enriched (HaCaT)
HPA (normal tissue):	Tissue enhanced (esophagus, skin, thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA041578
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041578

GENE INFORMATION
Gene name	DUOXA1 (HGNC Symbol)
Synonyms	FLJ32334, mol, NIP, NUMBIP
Description	Dual oxidase maturation factor 1 (HGNC Symbol)
Entrez gene summary	Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]
Chromosome	15
Cytoband	q21.1
Chromosome location (bp)	45117367 - 45129938
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140254 (version 83.38)
Entrez gene	90527
UniProt	Q1HG43 (UniProt - Evidence at protein level)
neXtProt	NX_Q1HG43
Antibodypedia	DUOXA1 antibodies

PROTEIN BROWSER

DUOXA1-001	DUOXA1-002	DUOXA1-003	DUOXA1-004	DUOXA1-005	DUOXA1-006	DUOXA1-008	DUOXA1-009	DUOXA1-011	DUOXA1-012	DUOXA1-014	DUOXA1-015	DUOXA1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DUOXA1-001 ENSP00000267803 ENST00000267803	Q1HG43 [Direct mapping] Dual oxidase maturation factor 1 A8K9Q6 [Target identity:100%; Query identity:100%] Dual oxidase maturation factor 1 gamma; Homolog of Drosophila Numb-interacting protein, isoform CRA_b; cDNA FLJ76085, highly similar to Homo sapiens homolog of Drosophila Numb-interacting protein (NIP), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] GO:0042743 [hydrogen peroxide metabolic process] GO:0045666 [positive regulation of neuron differentiation] GO:0050727 [regulation of inflammatory response] GO:2000379 [positive regulation of reactive oxygen species metabolic process] GO:2000609 [regulation of thyroid hormone generation] Show all	483 aa 53.5 kDa	No	5
DUOXA1-002 ENSP00000453569 ENST00000559014	Q1HG43 [Direct mapping] Dual oxidase maturation factor 1 A8K9Q6 [Target identity:100%; Query identity:100%] Dual oxidase maturation factor 1 gamma; Homolog of Drosophila Numb-interacting protein, isoform CRA_b; cDNA FLJ76085, highly similar to Homo sapiens homolog of Drosophila Numb-interacting protein (NIP), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	483 aa 53.5 kDa	No	5
DUOXA1-003 ENSP00000453836 ENST00000558422	Q1HG43 [Direct mapping] Dual oxidase maturation factor 1 B5M0B8 [Target identity:100%; Query identity:100%] Dual oxidase maturation factor 1 beta; Homolog of Drosophila Numb-interacting protein, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	298 aa 33.1 kDa	No	5
DUOXA1-004 ENSP00000454019 ENST00000558996	Q1HG43 [Direct mapping] Dual oxidase maturation factor 1 B5M0B8 [Target identity:100%; Query identity:100%] Dual oxidase maturation factor 1 beta; Homolog of Drosophila Numb-interacting protein, isoform CRA_a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	298 aa 33.1 kDa	No	5
DUOXA1-005 ENSP00000454084 ENST00000560572	Q1HG43 [Direct mapping] Dual oxidase maturation factor 1 B5M0B7 [Target identity:100%; Query identity:100%] Dual oxidase maturation factor 1 alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	343 aa 37.8 kDa	No	5
DUOXA1-006 ENSP00000415512 ENST00000430224	B5M0C0 [Direct mapping] Dual oxidase maturation factor 1; Dual oxidase maturation factor 1 delta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	438 aa 48.8 kDa	No	5
DUOXA1-008 ENSP00000452795 ENST00000559644	H0YKG3 [Direct mapping] Dual oxidase maturation factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		16 aa 1.7 kDa	No	0
DUOXA1-009 ENSP00000453295 ENST00000558377	H0YLQ4 [Direct mapping] Dual oxidase maturation factor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	72 aa 7.9 kDa	No	2
DUOXA1-011 ENSP00000454117 ENST00000558326	H0YNR1 [Direct mapping] Dual oxidase maturation factor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	77 aa 8.4 kDa	No	2
DUOXA1-012 ENSP00000452782 ENST00000559226	H0YKF3 [Direct mapping] Dual oxidase maturation factor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	72 aa 7.8 kDa	No	2
DUOXA1-014 ENSP00000453809 ENST00000559988	H0YMZ8 [Direct mapping] Dual oxidase maturation factor 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	121 aa 13 kDa	No	2
DUOXA1-015 ENSP00000453217 ENST00000558851	H0YLI1 [Direct mapping] Dual oxidase maturation factor 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		13 aa 1.4 kDa	No	0
DUOXA1-201 ENSP00000480154 ENST00000613425	B5M0C0 [Direct mapping] Dual oxidase maturation factor 1; Dual oxidase maturation factor 1 delta Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005789 [endoplasmic reticulum membrane] GO:0015031 [protein transport] GO:0016021 [integral component of membrane] Show all	438 aa 48.8 kDa	No	5

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