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DUOXA2

GENERAL INFORMATION

Gene name

 DUOXA2

Gene description

 Dual oxidase maturation factor 2

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (gallbladder, urinary bladder)
GTEx:Tissue enhanced (stomach, thyroid gland, vagina)
FANTOM5:Tissue enhanced (gallbladder, thyroid gland)

Protein evidence

 Evidence at protein level

Protein expression

 Luminal membranous expression in gallbladder and cytoplasmic expression in urothelium.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA063548
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Gallbladder

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, urinary bladder)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (stomach, thyroid gland, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (gallbladder, thyroid gland)

GENE INFORMATION

Gene name

 DUOXA2

Synonyms

Description

 Dual oxidase maturation factor 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an endoplasmic reticulum protein that is necessary for proper cellular localization and maturation of functional dual oxidase 2. Mutations in this gene have been associated with thyroid dyshormonogenesis 5.[provided by RefSeq, Feb 2010]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 45114321 - 45118421

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140274 (version 83.38)

Entrez gene

 405753

UniProt

 Q1HG44 (UniProt - Evidence at protein level)

neXtProt

 NX_Q1HG44

Antibodypedia

 DUOXA2 antibodies

PROTEIN BROWSER
DUOXA2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUOXA2-001
ENSP00000319705
ENST00000323030
Q1HG44 [Direct mapping]
Dual oxidase maturation factor 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Disease related genes
Show all
GO:0005789 [endoplasmic reticulum membrane]
GO:0015031 [protein transport]
GO:0016021 [integral component of membrane]
GO:0042743 [hydrogen peroxide metabolic process]
GO:0050727 [regulation of inflammatory response]
GO:2000609 [regulation of thyroid hormone generation]
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 320 aa
34.8 kDa 		No 5

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.