Fields »
ABOUT
HELP
BLOG
DUOX2

GENERAL INFORMATION

Gene name

 DUOX2

Gene description

 Dual oxidase 2

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (thyroid cancer)
HPA (cell line):Cell line enriched (HaCaT)
HPA (normal tissue):Group enriched (gallbladder, thyroid gland, urinary bladder)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (thyroid cancer)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 DUOX2 (HGNC Symbol)

Synonyms

 LNOX2, P138(TOX), P138-TOX, THOX2

Description

 Dual oxidase 2 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a glycoprotein and a member of the NADPH oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q21.1

Chromosome location (bp)

 45092650 - 45114344

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140279 (version 83.38)

Entrez gene

 50506

UniProt

 Q9NRD8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NRD8

Antibodypedia

 DUOX2 antibodies

PROTEIN BROWSER
DUOX2-001
DUOX2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUOX2-001
ENSP00000373691
ENST00000389039
X6RAN8 [Direct mapping]
Dual oxidase 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Show all
GO:0004601 [peroxidase activity]
GO:0005509 [calcium ion binding]
GO:0006979 [response to oxidative stress]
GO:0016021 [integral component of membrane]
GO:0016491 [oxidoreductase activity]
GO:0020037 [heme binding]
GO:0055114 [oxidation-reduction process]
Show all
 1548 aa
175.3 kDa 		Yes 9
DUOX2-201
ENSP00000475084
ENST00000603300
Q9NRD8 [Direct mapping]
Dual oxidase 2
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
Transporters
   Transport Electron Carriers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0004601 [peroxidase activity]
GO:0005509 [calcium ion binding]
GO:0005886 [plasma membrane]
GO:0006590 [thyroid hormone generation]
GO:0006979 [response to oxidative stress]
GO:0009566 [fertilization]
GO:0009615 [response to virus]
GO:0016021 [integral component of membrane]
GO:0016174 [NAD(P)H oxidase activity]
GO:0016324 [apical plasma membrane]
GO:0016491 [oxidoreductase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0020037 [heme binding]
GO:0030282 [bone mineralization]
GO:0030878 [thyroid gland development]
GO:0034641 [cellular nitrogen compound metabolic process]
GO:0035264 [multicellular organism growth]
GO:0042335 [cuticle development]
GO:0042403 [thyroid hormone metabolic process]
GO:0042445 [hormone metabolic process]
GO:0042446 [hormone biosynthetic process]
GO:0042744 [hydrogen peroxide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0048839 [inner ear development]
GO:0048855 [adenohypophysis morphogenesis]
GO:0051591 [response to cAMP]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 1548 aa
175.4 kDa 		Yes 9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.