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Papillary adenocarcinomas of thyroid and cases of urothelial cancers showed moderate to strong cytoplasmic, nuclear and membranous immunoreactivity. Remaining cancer tissues were generally negative.
GENE INFORMATION
Gene name
FGF7 (HGNC Symbol)
Synonyms
KGF
Description
Fibroblast growth factor 7 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is a potent epithelial cell-specific growth factor, whose mitogenic activity is predominantly exhibited in keratinocytes but not in fibroblasts and endothelial cells. Studies of mouse and rat homologs of this gene implicated roles in morphogenesis of epithelium, reepithelialization of wounds, hair development and early lung organogenesis. [provided by RefSeq, Jul 2008]