Tissue expression of GCNT3 - Summary - The Human Protein Atlas

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GCNT3

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	GCNT3
Gene description	Glucosaminyl (N-acetyl) transferase 3, mucin type
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (colon, gallbladder, rectum, small intestine)
GTEx:	Tissue enhanced (colon, salivary gland, small intestine)
FANTOM5:	Tissue enhanced (small intestine)

Protein evidence

Evidence at protein level

Protein expression

Granular cytoplasmic expression in gastrointestinal mucosa.

DATA RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Approved based on 1 antibody. HPA011154
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, gallbladder, rectum, small intestine)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (colon, salivary gland, small intestine)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (small intestine)

GENE INFORMATION
Gene name	GCNT3 (HGNC Symbol)
Synonyms	C2/4GnT, C2GnT-M, C2GnT2
Description	Glucosaminyl (N-acetyl) transferase 3, mucin type (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the N-acetylglucosaminyltransferase family. The encoded protein is a beta-6-N-acetylglucosamine-transferase that catalyzes the formation of core 2 and core 4 O-glycans on mucin-type glycoproteins.[provided by RefSeq, Apr 2009]
Chromosome	15
Cytoband	q22.2
Chromosome location (bp)	59594875 - 59640239
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140297 (version 83.38)
Entrez gene	9245
UniProt	O95395 (UniProt - Evidence at transcript level)
neXtProt	NX_O95395
Antibodypedia	GCNT3 antibodies

PROTEIN BROWSER

GCNT3-001	GCNT3-005	GCNT3-007	GCNT3-008	GCNT3-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCNT3-001 ENSP00000379377 ENST00000396065	O95395 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 A0A024R5T9 [Target identity:100%; Query identity:100%] Glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0002426 [immunoglobulin production in mucosal tissue] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0047225 [acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0048729 [tissue morphogenesis] GO:0050892 [intestinal absorption] GO:0060993 [kidney morphogenesis] GO:0070062 [extracellular exosome] Show all	438 aa 50.9 kDa	No	1
GCNT3-005 ENSP00000453453 ENST00000559189	H0YM40 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	87 aa 10 kDa	No	1
GCNT3-007 ENSP00000453928 ENST00000559626	H0YNA3 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	53 aa 6.3 kDa	No	1
GCNT3-008 ENSP00000452741 ENST00000560585	O95395 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 A0A024R5T9 [Target identity:100%; Query identity:100%] Glucosaminyl (N-acetyl) transferase 3, mucin type, isoform CRA_a Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003829 [beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity] GO:0005975 [carbohydrate metabolic process] GO:0006493 [protein O-linked glycosylation] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016266 [O-glycan processing] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0070062 [extracellular exosome] Show all	438 aa 50.9 kDa	No	1
GCNT3-010 ENSP00000453774 ENST00000559200	H0YMW7 [Direct mapping] Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	153 aa 18 kDa	No	1

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The Human Protein Atlas

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