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BNIP2

GENERAL INFORMATION

Gene name

 BNIP2

Gene description

 BCL2/adenovirus E1B 19kDa interacting protein 2

Protein class

 Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA026843
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 BNIP2 (HGNC Symbol)

Synonyms

 BNIP-2, Nip2

Description

 BCL2/adenovirus E1B 19kDa interacting protein 2 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein (BNIP) family. It interacts with the E1B 19 kDa protein, which protects cells from virally-induced cell death. The encoded protein also interacts with E1B 19 kDa-like sequences of BCL2, another apoptotic protector. [provided by RefSeq, Mar 2011]

Chromosome

 15

Cytoband

 q22.2

Chromosome location (bp)

 59659146 - 59689534

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140299 (version 83.38)

Entrez gene

 663

UniProt

 Q12982 (UniProt - Evidence at protein level)

neXtProt

 NX_Q12982

Antibodypedia

 BNIP2 antibodies

PROTEIN BROWSER
BNIP2-001
BNIP2-006
BNIP2-008
BNIP2-012
BNIP2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
BNIP2-001
ENSP00000267859
ENST00000267859
J3KN59 [Direct mapping]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001824 [blastocyst development]
GO:0005814 [centriole]
GO:0005829 [cytosol]
GO:0031616 [spindle pole centrosome]
GO:0042802 [identical protein binding]
GO:0043410 [positive regulation of MAPK cascade]
GO:0045666 [positive regulation of neuron differentiation]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051146 [striated muscle cell differentiation]
GO:0051297 [centrosome organization]
Show all
 435 aa
48.8 kDa 		No 0
BNIP2-006
ENSP00000393644
ENST00000439052
H7C096 [Direct mapping]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0016021 [integral component of membrane]
GO:0042802 [identical protein binding]
Show all
 204 aa
24.2 kDa 		No 1
BNIP2-008
ENSP00000412767
ENST00000415213
Q12982 [Direct mapping]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051149 [positive regulation of muscle cell differentiation]
Show all
 376 aa
43.1 kDa 		No 0
BNIP2-012
ENSP00000475320
ENST00000607373
Q12982 [Direct mapping]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005096 [GTPase activator activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005635 [nuclear envelope]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006915 [apoptotic process]
GO:0042692 [muscle cell differentiation]
GO:0042802 [identical protein binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043547 [positive regulation of GTPase activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0051149 [positive regulation of muscle cell differentiation]
Show all
 314 aa
36 kDa 		No 0
BNIP2-201
ENSP00000479818
ENST00000612191
J3KN59 [Direct mapping]
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005829 [cytosol]
GO:0042802 [identical protein binding]
Show all
 435 aa
48.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.