We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Several cases of gliomas, colorectal, breast, pancreatic, prostate, skin cancers along with a few cases of urothelial, endometrial, thyroid, head and neck cancers showed moderate nuclear positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
TLE3 (HGNC Symbol)
Synonyms
ESG, ESG3, GRG3, HsT18976, KIAA1547
Description
Transducin-like enhancer of split 3 (HGNC Symbol)
Entrez gene summary
This gene encodes a transcriptional co-repressor protein that belongs to the transducin-like enhancer family of proteins. The members of this family function in the Notch signaling pathway that regulates determination of cell fate during development. Expression of this gene has been associated with a favorable outcome to chemotherapy with taxanes for ovarian carcinoma. Alternate splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Sep 2013]