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Gliomas, colorectal, lung and pancreatic cancers mainly displayed moderate to strong granular cytoplasmic positivity. Lymphomas, skin, testis, breast and cervical cancers were mainly negative. Remaining cancers displayed weak to moderate staining.
GENE INFORMATION
Gene name
TSPAN3 (HGNC Symbol)
Synonyms
TM4-A, TM4SF8, TSPAN-3
Description
Tetraspanin 3 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The use of alternate polyadenylation sites has been found for this gene. Multiple alternative transcripts encoding different isoforms have been described. [provided by RefSeq, Dec 2009]