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The NCOA2 gene encodes nuclear receptor coactivator 2, which aids in the function of nuclear hormone receptors. Nuclear hormone receptors are conditional transcription factors that play important roles in various aspects of cell growth, development, and homeostasis by controlling expression of specific genes. Members of the nuclear hormone receptor superfamily, which includes the 5 steroid receptors and class II nuclear receptors (see below), are structurally characterized by 3 distinct domains: an N-terminal transcriptional activation domain, a central DNA-binding domain, and a C-terminal hormone-binding domain. Before the binding of hormone, steroid receptors, which are sometimes called class I of the nuclear hormone receptor family, remain inactive in a complex with heat-shock protein-90 (MIM 140571) and other stress family proteins. Binding of hormone induces critical conformational changes in steroid receptors that cause them to dissociate from the inhibitory complex, bind as homodimers to specific DNA enhancer elements associated with target genes, and modulate that gene's transcription. After binding to enhancer elements, transcription factors require transcriptional coactivator proteins to mediate their stimulation of transcription initiation (Hong et al., 1997 [PubMed 9111344]).[supplied by OMIM, Nov 2010]
Predicted intracellular proteins Transcription factors Basic domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0001162 [RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding] GO:0003682 [chromatin binding] GO:0003713 [transcription coactivator activity] GO:0004402 [histone acetyltransferase activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005791 [rough endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005874 [microtubule] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007264 [small GTPase mediated signal transduction] GO:0007623 [circadian rhythm] GO:0008134 [transcription factor binding] GO:0008206 [bile acid metabolic process] GO:0008584 [male gonad development] GO:0010906 [regulation of glucose metabolic process] GO:0014069 [postsynaptic density] GO:0015721 [bile acid and bile salt transport] GO:0016573 [histone acetylation] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0021549 [cerebellum development] GO:0030165 [PDZ domain binding] GO:0030331 [estrogen receptor binding] GO:0030374 [ligand-dependent nuclear receptor transcription coactivator activity] GO:0030375 [thyroid hormone receptor coactivator activity] GO:0030425 [dendrite] GO:0032403 [protein complex binding] GO:0032870 [cellular response to hormone stimulus] GO:0032922 [circadian regulation of gene expression] GO:0033142 [progesterone receptor binding] GO:0035257 [nuclear hormone receptor binding] GO:0035259 [glucocorticoid receptor binding] GO:0042974 [retinoic acid receptor binding] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045475 [locomotor rhythm] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045925 [positive regulation of female receptivity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046965 [retinoid X receptor binding] GO:0046966 [thyroid hormone receptor binding] GO:0046983 [protein dimerization activity] GO:0048786 [presynaptic active zone] GO:0070182 [DNA polymerase binding] GO:1904017 [cellular response to Thyroglobulin triiodothyronine] GO:2000273 [positive regulation of receptor activity] GO:2000324 [positive regulation of glucocorticoid receptor signaling pathway]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0005634 [nucleus] GO:0032870 [cellular response to hormone stimulus] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014)
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GO:0003713 [transcription coactivator activity] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0032870 [cellular response to hormone stimulus] GO:0035257 [nuclear hormone receptor binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
