Expression of HAPLN3 in cancer - Summary - The Human Protein Atlas

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HAPLN3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HAPLN3
Gene description	Hyaluronan and proteoglycan link protein 3
Protein class	Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HDLM-2, U-2 OS)
HPA (normal tissue):	Tissue enhanced (appendix, lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including secreted positivity.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending retesting and verification.
Reliability score	Uncertain based on 1 antibody. HPA039237
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039237

GENE INFORMATION
Gene name	HAPLN3 (HGNC Symbol)
Synonyms	EXLD1, HsT19883
Description	Hyaluronan and proteoglycan link protein 3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the hyaluronan and proteoglycan binding link protein gene family. The protein encoded by this gene may function in hyaluronic acid binding and cell adhesion. [provided by RefSeq, Jul 2008]
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	88877288 - 88895626
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140511 (version 83.38)
Entrez gene	145864
UniProt	Q96S86 (UniProt - Evidence at transcript level)
neXtProt	NX_Q96S86
Antibodypedia	HAPLN3 antibodies

PROTEIN BROWSER

HAPLN3-001	HAPLN3-003	HAPLN3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HAPLN3-001 ENSP00000352606 ENST00000359595	Q96S86 [Direct mapping] Hyaluronan and proteoglycan link protein 3 A0A024RC58 [Target identity:100%; Query identity:100%] Hyaluronan and proteoglycan link protein 3, isoform CRA_a Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0005615 [extracellular space] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	360 aa 40.9 kDa	Yes	0
HAPLN3-003 ENSP00000457180 ENST00000562889	H3BTH8 [Direct mapping] Hyaluronan and proteoglycan link protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	422 aa 47.8 kDa	No	1
HAPLN3-004 ENSP00000456985 ENST00000562281	H3BT26 [Direct mapping] Hyaluronan and proteoglycan link protein 3 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001501 [skeletal system development] GO:0005515 [protein binding] GO:0005540 [hyaluronic acid binding] GO:0005578 [proteinaceous extracellular matrix] GO:0007155 [cell adhesion] GO:0007417 [central nervous system development] Show all	226 aa 25.4 kDa	Yes	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.