Expression of RHCG in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	RHCG
Gene description	Rh family, C glycoprotein
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (cervical cancer, head and neck cancer)
HPA (cell line):	Cell line enhanced (A549, hTCEpi, RT4)
HPA (normal tissue):	Tissue enriched (esophagus)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective basolateral membrane expression in renal tubules with membranous and cytoplasmic expression in squamous epithelia.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA041874 , HPA043317
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (unfavourable).
Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (cervical cancer, head and neck cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041874	HPA043317

GENE INFORMATION
Gene name	RHCG (HGNC Symbol)
Synonyms	C15orf6, PDRC2, RHGK, SLC42A3
Description	Rh family, C glycoprotein (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q26.1
Chromosome location (bp)	89471398 - 89496613
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140519 (version 83.38)
Entrez gene	51458
UniProt	Q9UBD6 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBD6
Antibodypedia	RHCG antibodies

PROTEIN BROWSER

RHCG-001	RHCG-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RHCG-001 ENSP00000268122 ENST00000268122	Q9UBD6 [Direct mapping] Ammonium transporter Rh type C Show all	Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006873 [cellular ion homeostasis] GO:0006885 [regulation of pH] GO:0008519 [ammonium transmembrane transporter activity] GO:0015696 [ammonium transport] GO:0015837 [amine transport] GO:0016020 [membrane] GO:0016323 [basolateral plasma membrane] GO:0016324 [apical plasma membrane] GO:0030506 [ankyrin binding] GO:0030855 [epithelial cell differentiation] GO:0031410 [cytoplasmic vesicle] GO:0042592 [homeostatic process] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:0070634 [transepithelial ammonium transport] GO:0072488 [ammonium transmembrane transport] Show all	479 aa 53.2 kDa	No	>9
RHCG-005 ENSP00000453496 ENST00000558360	H0YM79 [Direct mapping] Ammonium transporter Rh type C Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008519 [ammonium transmembrane transporter activity] GO:0015696 [ammonium transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0072488 [ammonium transmembrane transport] Show all	237 aa 24.9 kDa	No	5