Fields »
ABOUT
HELP
BLOG
POLG

GENERAL INFORMATION

Gene name

 POLG

Gene description

 Polymerase (DNA directed), gamma

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Erythrocyte staining is viewed as off target binding and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA056821
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in prostate cancer (unfavourable).
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA056821

GENE INFORMATION

Gene name

 POLG (HGNC Symbol)

Synonyms

 POLG1, POLGA

Description

 Polymerase (DNA directed), gamma (HGNC Symbol)

Entrez gene summary

 Mitochondrial DNA polymerase is heterotrimeric, consisting of a homodimer of accessory subunits plus a catalytic subunit. The protein encoded by this gene is the catalytic subunit of mitochondrial DNA polymerase. The encoded protein contains a polyglutamine tract near its N-terminus that may be polymorphic. Defects in this gene are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions 1 (PEOA1), sensory ataxic neuropathy dysarthria and ophthalmoparesis (SANDO), Alpers-Huttenlocher syndrome (AHS), and mitochondrial neurogastrointestinal encephalopathy syndrome (MNGIE). Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q26.1

Chromosome location (bp)

 89316305 - 89334861

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140521 (version 83.38)

Entrez gene

 5428

UniProt

 P54098 (UniProt - Evidence at protein level)

neXtProt

 NX_P54098

Antibodypedia

 POLG antibodies

PROTEIN BROWSER
POLG-001
POLG-002
POLG-013

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
POLG-001
ENSP00000268124
ENST00000268124
P54098 [Direct mapping]
DNA polymerase subunit gamma-1
E5KNU5 [Target identity:100%; Query identity:100%]
DNA polymerase subunit gamma-1; Polymerase (DNA directed), gamma, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0004527 [exonuclease activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005760 [gamma DNA polymerase complex]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006264 [mitochondrial DNA replication]
GO:0006287 [base-excision repair, gap-filling]
GO:0007568 [aging]
GO:0008408 [3'-5' exonuclease activity]
GO:0009416 [response to light stimulus]
GO:0010332 [response to gamma radiation]
GO:0042645 [mitochondrial nucleoid]
GO:0043195 [terminal bouton]
GO:0043234 [protein complex]
GO:0055093 [response to hyperoxia]
GO:0070062 [extracellular exosome]
GO:0071333 [cellular response to glucose stimulus]
GO:0071897 [DNA biosynthetic process]
Show all
 1239 aa
139.6 kDa 		No 0
POLG-002
ENSP00000399851
ENST00000442287
P54098 [Direct mapping]
DNA polymerase subunit gamma-1
E5KNU5 [Target identity:100%; Query identity:100%]
DNA polymerase subunit gamma-1; Polymerase (DNA directed), gamma, isoform CRA_a
Show all
Enzymes
   ENZYME proteins
   Transferases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0002020 [protease binding]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005760 [gamma DNA polymerase complex]
GO:0006259 [DNA metabolic process]
GO:0006260 [DNA replication]
GO:0006261 [DNA-dependent DNA replication]
GO:0006264 [mitochondrial DNA replication]
GO:0006287 [base-excision repair, gap-filling]
GO:0008408 [3'-5' exonuclease activity]
GO:0042645 [mitochondrial nucleoid]
GO:0043234 [protein complex]
GO:0070062 [extracellular exosome]
GO:0071897 [DNA biosynthetic process]
Show all
 1239 aa
139.6 kDa 		No 0
POLG-013
ENSP00000432389
ENST00000526314
H0YCV2 [Direct mapping]
DNA polymerase subunit gamma-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003887 [DNA-directed DNA polymerase activity]
GO:0005760 [gamma DNA polymerase complex]
GO:0006260 [DNA replication]
Show all
 233 aa
25.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.