Expression of GLYR1 in cancer - Summary - The Human Protein Atlas

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GLYR1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GLYR1
Gene description	Glyoxylate reductase 1 homolog (Arabidopsis)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in all cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA048226 , HPA050136 , CAB017022
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA048226	HPA050136	CAB017022

GENE INFORMATION
Gene name	GLYR1 (HGNC Symbol)
Synonyms	BM045, HIBDL, N-PAC, NP60
Description	Glyoxylate reductase 1 homolog (Arabidopsis) (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	4803203 - 4847342
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140632 (version 83.38)
Entrez gene	84656
UniProt	Q49A26 (UniProt - Evidence at protein level)
neXtProt	NX_Q49A26
Antibodypedia	GLYR1 antibodies

PROTEIN BROWSER

GLYR1-001	GLYR1-002	GLYR1-004	GLYR1-005	GLYR1-007	GLYR1-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLYR1-001 ENSP00000322716 ENST00000321919	Q49A26 [Direct mapping] Putative oxidoreductase GLYR1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0035064 [methylated histone binding] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	553 aa 60.5 kDa	No	0
GLYR1-002 ENSP00000390276 ENST00000436648	Q49A26 [Direct mapping] Putative oxidoreductase GLYR1 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0035064 [methylated histone binding] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	472 aa 51.5 kDa	No	0
GLYR1-004 ENSP00000467751 ENST00000588297	K7EQB2 [Direct mapping] Putative oxidoreductase GLYR1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	186 aa 20.6 kDa	No	0
GLYR1-005 ENSP00000466570 ENST00000589389	K7EMM8 [Direct mapping] Putative oxidoreductase GLYR1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	524 aa 57.2 kDa	No	0
GLYR1-007 ENSP00000468328 ENST00000591451	Q49A26 [Direct mapping] Putative oxidoreductase GLYR1 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0004616 [phosphogluconate dehydrogenase (decarboxylating) activity] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005794 [Golgi apparatus] GO:0035064 [methylated histone binding] GO:0051287 [NAD binding] GO:0055114 [oxidation-reduction process] Show all	547 aa 59.8 kDa	No	0
GLYR1-009 ENSP00000467541 ENST00000587297	K7EPU6 [Direct mapping] Putative oxidoreductase GLYR1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] Show all	171 aa 18.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.