Cell atlas - SLC5A2 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

SLC5A2

premium

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	SLC5A2
Gene description	Solute carrier family 5 (sodium/glucose cotransporter), member 2
Protein class	Disease related genes FDA approved drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Not detected
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Not detected Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	SLC5A2 (HGNC Symbol)
Synonyms	SGLT2
Description	Solute carrier family 5 (sodium/glucose cotransporter), member 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene. [provided by RefSeq, Feb 2015]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31483002 - 31490860
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140675 (version 83.38)
Entrez gene	6524
UniProt	P31639 (UniProt - Evidence at protein level)
neXtProt	NX_P31639
Antibodypedia	SLC5A2 antibodies

PROTEIN BROWSER

SLC5A2-001	SLC5A2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC5A2-001 ENSP00000327943 ENST00000330498	P31639 [Direct mapping] Sodium/glucose cotransporter 2 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes FDA approved drug targets Small molecule drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0005362 [low-affinity glucose:sodium symporter activity] GO:0005412 [glucose:sodium symporter activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005975 [carbohydrate metabolic process] GO:0006810 [transport] GO:0006814 [sodium ion transport] GO:0015758 [glucose transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031526 [brush border membrane] GO:0055085 [transmembrane transport] GO:0070062 [extracellular exosome] GO:1904659 [glucose transmembrane transport] Show all	672 aa 72.9 kDa	No	>9
SLC5A2-005 ENSP00000455143 ENST00000569576	H3BP44 [Direct mapping] Sodium/glucose cotransporter 2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005215 [transporter activity] GO:0006810 [transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	149 aa 16.1 kDa	No	4

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.