Expression of ITGAX in cancer - Summary - The Human Protein Atlas

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ITGAX

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ITGAX
Gene description	Integrin, alpha X (complement component 3 receptor 4 subunit)
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enriched (HMC-1)
HPA (normal tissue):	Tissue enhanced (appendix, spleen)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in macrophages and cells in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA004723 , CAB004458 , CAB072871
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004723	CAB004458	CAB072871

GENE INFORMATION
Gene name	ITGAX (HGNC Symbol)
Synonyms	CD11C
Description	Integrin, alpha X (complement component 3 receptor 4 subunit) (HGNC Symbol)
Entrez gene summary	This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4). The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Chromosome	16
Cytoband	p11.2
Chromosome location (bp)	31355134 - 31382997
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140678 (version 83.38)
Entrez gene	3687
UniProt	P20702 (UniProt - Evidence at protein level)
neXtProt	NX_P20702
Antibodypedia	ITGAX antibodies

PROTEIN BROWSER

ITGAX-001	ITGAX-003	ITGAX-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITGAX-001 ENSP00000268296 ENST00000268296	P20702 [Direct mapping] Integrin alpha-X Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004872 [receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0007596 [blood coagulation] GO:0008305 [integrin complex] GO:0009887 [organ morphogenesis] GO:0009986 [cell surface] GO:0016020 [membrane] GO:0030198 [extracellular matrix organization] GO:0034113 [heterotypic cell-cell adhesion] GO:0046872 [metal ion binding] GO:0050900 [leukocyte migration] GO:1903955 [positive regulation of protein targeting to mitochondrion] Show all	1163 aa 127.8 kDa	Yes	1
ITGAX-003 ENSP00000483860 ENST00000562918	A0A087X131 [Direct mapping] Integrin alpha-X Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		181 aa 19.7 kDa	Yes	0
ITGAX-004 ENSP00000454623 ENST00000562522	H3BN02 [Direct mapping] Integrin alpha-X Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0007155 [cell adhesion] GO:0007229 [integrin-mediated signaling pathway] GO:0008305 [integrin complex] GO:0009897 [external side of plasma membrane] GO:0051607 [defense response to virus] Show all	1169 aa 128.5 kDa	Yes	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.