Fields »
ABOUT
HELP
BLOG
UQCRC2

GENERAL INFORMATION

Gene name

 UQCRC2

Gene description

 Ubiquinol-cytochrome c reductase core protein II

Protein class

 Disease related genes
Enzymes
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 General cytoplasmic expression with a granular pattern.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA007998 , HPA019146
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Heart muscle

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 UQCRC2 (HGNC Symbol)

Synonyms

 QCR2, UQCR2

Description

 Ubiquinol-cytochrome c reductase core protein II (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]

Chromosome

 16

Cytoband

 p12.2

Chromosome location (bp)

 21952660 - 21983660

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140740 (version 83.38)

Entrez gene

 7385

UniProt

 P22695 (UniProt - Evidence at protein level)

neXtProt

 NX_P22695

Antibodypedia

 UQCRC2 antibodies

PROTEIN BROWSER
UQCRC2-001
UQCRC2-003
UQCRC2-005
UQCRC2-012
UQCRC2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
UQCRC2-001
ENSP00000268379
ENST00000268379
P22695 [Direct mapping]
Cytochrome b-c1 complex subunit 2, mitochondrial
Show all
Enzymes
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005515 [protein binding]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005750 [mitochondrial respiratory chain complex III]
GO:0006119 [oxidative phosphorylation]
GO:0006122 [mitochondrial electron transport, ubiquinol to cytochrome c]
GO:0006508 [proteolysis]
GO:0008270 [zinc ion binding]
GO:0009060 [aerobic respiration]
GO:0016485 [protein processing]
GO:0022904 [respiratory electron transport chain]
GO:0032403 [protein complex binding]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0046872 [metal ion binding]
GO:0070062 [extracellular exosome]
Show all
 453 aa
48.4 kDa 		No 0
UQCRC2-003
ENSP00000456232
ENST00000561553
H3BRG4 [Direct mapping]
Cytochrome b-c1 complex subunit 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
GO:0046872 [metal ion binding]
Show all
 412 aa
44.6 kDa 		No 0
UQCRC2-005
ENSP00000455088
ENST00000565331
H3BP04 [Direct mapping]
Cytochrome b-c1 complex subunit 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0005739 [mitochondrion]
GO:0006508 [proteolysis]
GO:0046872 [metal ion binding]
Show all
 176 aa
19.5 kDa 		No 0
UQCRC2-012
ENSP00000479799
ENST00000618892
A0A087WVZ4 [Direct mapping]
Cytochrome b-c1 complex subunit 2, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0046872 [metal ion binding]
Show all
 70 aa
7.5 kDa 		No 0
UQCRC2-201
ENSP00000485966
ENST00000630839
H3BUI9 [Direct mapping]
Cytochrome b-c1 complex subunit 2, mitochondrial; Ubiquinol-cytochrome c reductase core protein II, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004222 [metalloendopeptidase activity]
GO:0006508 [proteolysis]
GO:0046872 [metal ion binding]
Show all
 132 aa
14.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.