Cell atlas - MYLK3 - The Human Protein Atlas

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MYLK3

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION

GENE/PROTEIN

Dictionary

Human cell

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GENERAL INFORMATION
Gene name	MYLK3
Gene description	Myosin light chain kinase 3
Protein class	Enzymes Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary
RNA cell category	Cell line enhanced (HEL, BEWO)
Protein evidence	Evidence at protein level
Main location	Not available

DATA RELIABILITY
Reliability score	Pending cell analysis.

ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (HEL, BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

GENE INFORMATION
Gene name	MYLK3 (HGNC Symbol)
Synonyms	caMLCK, MLCK
Description	Myosin light chain kinase 3 (HGNC Symbol)
Entrez gene summary	Phosphorylation of cardiac myosin heavy chains (see MYH7B, MIM 609928) and light chains (see MYL2, MIM 160781) by a kinase, such as MYLK3, potentiates the force and rate of cross-bridge recruitment in cardiac myocytes (Chan et al., 2008 [PubMed 18202317]).[supplied by OMIM, Jul 2008]
Chromosome	16
Cytoband	q11.2
Chromosome location (bp)	46703369 - 46790407
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140795 (version 83.38)
Entrez gene	91807
UniProt	Q32MK0 (UniProt - Evidence at transcript level)
neXtProt	NX_Q32MK0
Antibodypedia	MYLK3 antibodies

PROTEIN BROWSER

MYLK3-001	MYLK3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MYLK3-001 ENSP00000378288 ENST00000394809	Q32MK0 [Direct mapping] Myosin light chain kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002528 [regulation of vascular permeability involved in acute inflammatory response] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004687 [myosin light chain kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0015629 [actin cytoskeleton] GO:0045214 [sarcomere organization] GO:0048769 [sarcomerogenesis] GO:0055003 [cardiac myofibril assembly] GO:0060298 [positive regulation of sarcomere organization] GO:0071347 [cellular response to interleukin-1] Show all	819 aa 88.4 kDa	No	1
MYLK3-003 ENSP00000439297 ENST00000536476	Q32MK0 [Direct mapping] Myosin light chain kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002528 [regulation of vascular permeability involved in acute inflammatory response] GO:0004672 [protein kinase activity] GO:0004683 [calmodulin-dependent protein kinase activity] GO:0004687 [myosin light chain kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006468 [protein phosphorylation] GO:0045214 [sarcomere organization] GO:0048769 [sarcomerogenesis] GO:0055003 [cardiac myofibril assembly] GO:0060298 [positive regulation of sarcomere organization] GO:0071347 [cellular response to interleukin-1] Show all	478 aa 52.7 kDa	No	1

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.