Expression of CHST4 in cancer - Summary

GENERAL INFORMATION
Gene name	CHST4
Gene description	Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (pancreatic cancer)
HPA (cell line):	Cell line enhanced (CAPAN-2, NB-4, NTERA-2, SCLC-21H)
HPA (normal tissue):	Tissue enriched (gallbladder)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular expression primarily in gallbladder but also in fallopian tube, pancreas and liver.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA021955
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (pancreatic cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

HPA021955

GENE INFORMATION
Gene name	CHST4 (HGNC Symbol)
Synonyms	HEC-GLCNAC-6-ST, LSST
Description	Carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes an N-acetylglucosamine 6-O sulfotransferase. The encoded enzyme transfers sulfate from 3'phosphoadenosine 5'phospho-sulfate to the 6-hydroxyl group of N-acetylglucosamine on glycoproteins. This protein is localized to the Golgi and is involved in the modification of glycan structures on ligands of the lymphocyte homing receptor L-selectin. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Chromosome	16
Cytoband	q22.2
Chromosome location (bp)	71525233 - 71538746
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140835 (version 83.38)
Entrez gene	10164
UniProt	Q8NCG5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NCG5
Antibodypedia	CHST4 antibodies

PROTEIN BROWSER

CHST4-001	CHST4-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHST4-001 ENSP00000341206 ENST00000338482	Q8NCG5 [Direct mapping] Carbohydrate sulfotransferase 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006477 [protein sulfation] GO:0006790 [sulfur compound metabolic process] GO:0006928 [movement of cell or subcellular component] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0031228 [intrinsic component of Golgi membrane] Show all	386 aa 45.1 kDa	Yes	0
CHST4-002 ENSP00000441204 ENST00000539698	Q8NCG5 [Direct mapping] Carbohydrate sulfotransferase 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0001517 [N-acetylglucosamine 6-O-sulfotransferase activity] GO:0005802 [trans-Golgi network] GO:0005975 [carbohydrate metabolic process] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006477 [protein sulfation] GO:0006790 [sulfur compound metabolic process] GO:0006928 [movement of cell or subcellular component] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007155 [cell adhesion] GO:0007267 [cell-cell signaling] GO:0008146 [sulfotransferase activity] GO:0016021 [integral component of membrane] GO:0031228 [intrinsic component of Golgi membrane] Show all	386 aa 45.1 kDa	Yes	0