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This gene encodes a member of the caspase recruitment domain-containing NLR family. This gene plays a role in cytokine response and antiviral immunity through its inhibition of NF-kappa-B activation and negative regulation of type I interferon signaling pathways. [provided by RefSeq, Oct 2011]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
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GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032480 [negative regulation of type I interferon production] GO:0043549 [regulation of kinase activity] GO:0045087 [innate immune response] GO:0045345 [positive regulation of MHC class I biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060335 [positive regulation of interferon-gamma-mediated signaling pathway] GO:0060339 [negative regulation of type I interferon-mediated signaling pathway] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032480 [negative regulation of type I interferon production] GO:0043549 [regulation of kinase activity] GO:0045087 [innate immune response] GO:0045345 [positive regulation of MHC class I biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060335 [positive regulation of interferon-gamma-mediated signaling pathway] GO:0060339 [negative regulation of type I interferon-mediated signaling pathway] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000979 [RNA polymerase II core promoter sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0032088 [negative regulation of NF-kappaB transcription factor activity] GO:0032480 [negative regulation of type I interferon production] GO:0043549 [regulation of kinase activity] GO:0045087 [innate immune response] GO:0045345 [positive regulation of MHC class I biosynthetic process] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0051607 [defense response to virus] GO:0060335 [positive regulation of interferon-gamma-mediated signaling pathway] GO:0060339 [negative regulation of type I interferon-mediated signaling pathway] GO:0060340 [positive regulation of type I interferon-mediated signaling pathway]