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NUDT7

GENERAL INFORMATION

Gene name

 NUDT7

Gene description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 7

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (THP-1, U-698)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression, often with a granular pattern.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA042042
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and head and neck cancer (unfavourable).
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA042042

GENE INFORMATION

Gene name

 NUDT7

Synonyms

Description

 Nudix (nucleoside diphosphate linked moiety X)-type motif 7 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Nudix hydrolase family. Nudix hydrolases eliminate potentially toxic nucleotide metabolites from the cell and regulate the concentrations and availability of many different nucleotide substrates, cofactors, and signaling molecules. Alternatively spliced transcript variants encoding multiple isoforms have been found for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 16

Cytoband

 q23.1

Chromosome location (bp)

 77722492 - 77742260

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140876 (version 83.38)

Entrez gene

 283927

UniProt

 P0C024 (UniProt - Evidence at transcript level)

neXtProt

 NX_P0C024

Antibodypedia

 NUDT7 antibodies

PROTEIN BROWSER
NUDT7-001
NUDT7-003
NUDT7-004
NUDT7-005
NUDT7-006
NUDT7-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NUDT7-001
ENSP00000387707
ENST00000437314
P0C024 [Direct mapping]
Peroxisomal coenzyme A diphosphatase NUDT7
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   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000287 [magnesium ion binding]
GO:0003674 [molecular_function]
GO:0003986 [acetyl-CoA hydrolase activity]
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0008150 [biological_process]
GO:0009132 [nucleoside diphosphate metabolic process]
GO:0015938 [coenzyme A catabolic process]
GO:0016787 [hydrolase activity]
GO:0030145 [manganese ion binding]
GO:0030515 [snoRNA binding]
GO:0046356 [acetyl-CoA catabolic process]
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 185 aa
21.2 kDa 		No 0
NUDT7-003
ENSP00000268533
ENST00000268533
P0C024 [Direct mapping]
Peroxisomal coenzyme A diphosphatase NUDT7
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003674 [molecular_function]
GO:0003986 [acetyl-CoA hydrolase activity]
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0008150 [biological_process]
GO:0009132 [nucleoside diphosphate metabolic process]
GO:0015938 [coenzyme A catabolic process]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030145 [manganese ion binding]
GO:0030515 [snoRNA binding]
GO:0046356 [acetyl-CoA catabolic process]
GO:0050873 [brown fat cell differentiation]
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 238 aa
26.9 kDa 		No 0
NUDT7-004
ENSP00000457566
ENST00000564085
P0C024 [Direct mapping]
Peroxisomal coenzyme A diphosphatase NUDT7
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003674 [molecular_function]
GO:0003986 [acetyl-CoA hydrolase activity]
GO:0005102 [receptor binding]
GO:0005777 [peroxisome]
GO:0008150 [biological_process]
GO:0009132 [nucleoside diphosphate metabolic process]
GO:0015938 [coenzyme A catabolic process]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030145 [manganese ion binding]
GO:0030515 [snoRNA binding]
GO:0046356 [acetyl-CoA catabolic process]
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 170 aa
18.7 kDa 		No 0
NUDT7-005
ENSP00000456363
ENST00000568787
H3BRQ8 [Direct mapping]
Peroxisomal coenzyme A diphosphatase NUDT7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0009132 [nucleoside diphosphate metabolic process]
GO:0016787 [hydrolase activity]
GO:0016818 [hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides]
GO:0030145 [manganese ion binding]
Show all
 120 aa
13.4 kDa 		No 0
NUDT7-006
ENSP00000454617
ENST00000563839
H3BMZ7 [Direct mapping]
Peroxisomal coenzyme A diphosphatase NUDT7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 15 aa
1.8 kDa 		No 0
NUDT7-201
ENSP00000479582
ENST00000613075
A0A087WVP7 [Direct mapping]
Peroxisomal coenzyme A diphosphatase NUDT7
Show all
   MEMSAT3 predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
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 223 aa
25.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.