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MAP1LC3B

GENERAL INFORMATION

Gene name

 MAP1LC3B

Gene description

 Microtubule-associated protein 1 light chain 3 beta

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Caution, targets protein from more than one gene. Pending external verification.

Reliability score

 Uncertain based on 4 antibodies.
HPA052474 , HPA052484 , HPA053767 , CAB037216
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and stomach cancer (unfavourable).
Renal cancer p<0.001
Stomach cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA052474
HPA052484
HPA053767
CAB037216

GENE INFORMATION

Gene name

 MAP1LC3B (HGNC Symbol)

Synonyms

 ATG8F

Description

 Microtubule-associated protein 1 light chain 3 beta (HGNC Symbol)

Entrez gene summary

 The product of this gene is a subunit of neuronal microtubule-associated MAP1A and MAP1B proteins, which are involved in microtubule assembly and important for neurogenesis. Studies on the rat homolog implicate a role for this gene in autophagy, a process that involves the bulk degradation of cytoplasmic component. [provided by RefSeq, Jul 2008]

Chromosome

 16

Cytoband

 q24.2

Chromosome location (bp)

 87383995 - 87404779

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000140941 (version 83.38)

Entrez gene

 81631

UniProt

 Q9GZQ8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9GZQ8

Antibodypedia

 MAP1LC3B antibodies

PROTEIN BROWSER
MAP1LC3B-001
MAP1LC3B-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MAP1LC3B-001
ENSP00000268607
ENST00000268607
Q9GZQ8 [Direct mapping]
Microtubule-associated proteins 1A/1B light chain 3B
Q658J6 [Target identity:100%; Query identity:100%]
Microtubule-associated protein 1 light chain 3 beta, isoform CRA_c; Putative uncharacterized protein DKFZp762B153; cDNA FLJ77661, highly similar to Homo sapiens microtubule-associated protein 1 light chain 3 beta(MAP1LC3B), mRNA
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Predicted intracellular proteins
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GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0000423 [macromitophagy]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005739 [mitochondrion]
GO:0005776 [autophagosome]
GO:0005829 [cytosol]
GO:0005874 [microtubule]
GO:0005930 [axoneme]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008017 [microtubule binding]
GO:0012505 [endomembrane system]
GO:0016236 [macroautophagy]
GO:0019898 [extrinsic component of membrane]
GO:0031090 [organelle membrane]
GO:0031410 [cytoplasmic vesicle]
GO:0031625 [ubiquitin protein ligase binding]
GO:0044804 [nucleophagy]
GO:0061025 [membrane fusion]
GO:1903146 [regulation of mitophagy]
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 125 aa
14.7 kDa 		No 0
MAP1LC3B-005
ENSP00000457225
ENST00000565788
H3BTL1 [Direct mapping]
Microtubule-associated protein 1 light chain 3 beta, isoform CRA_f; Microtubule-associated proteins 1A/1B light chain 3B
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Predicted intracellular proteins
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GO:0000045 [autophagosome assembly]
GO:0000407 [pre-autophagosomal structure]
GO:0000421 [autophagosome membrane]
GO:0000422 [mitophagy]
GO:0005829 [cytosol]
GO:0006995 [cellular response to nitrogen starvation]
GO:0008017 [microtubule binding]
GO:0019898 [extrinsic component of membrane]
GO:0044804 [nucleophagy]
GO:0061025 [membrane fusion]
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 75 aa
9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.