Expression of RPS2 in cancer - Summary - The Human Protein Atlas

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RPS2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RPS2
Gene description	Ribosomal protein S2
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Ribosomal proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA055133
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA055133

GENE INFORMATION
Gene name	RPS2 (HGNC Symbol)
Synonyms	LLREP3, S2
Description	Ribosomal protein S2 (HGNC Symbol)
Entrez gene summary	Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1962052 - 1964860
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140988 (version 83.38)
Entrez gene	6187
UniProt	P15880 (UniProt - Evidence at protein level)
neXtProt	NX_P15880
Antibodypedia	RPS2 antibodies

PROTEIN BROWSER

RPS2-001	RPS2-006	RPS2-007	RPS2-008	RPS2-013	RPS2-015	RPS2-017	RPS2-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RPS2-001 ENSP00000341885 ENST00000343262	P15880 [Direct mapping] 40S ribosomal protein S2 Show all	Ribosomal proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000184 [nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0003723 [RNA binding] GO:0003729 [mRNA binding] GO:0003735 [structural constituent of ribosome] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005840 [ribosome] GO:0005925 [focal adhesion] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0006414 [translational elongation] GO:0006415 [translational termination] GO:0006614 [SRP-dependent cotranslational protein targeting to membrane] GO:0010467 [gene expression] GO:0015935 [small ribosomal subunit] GO:0016020 [membrane] GO:0016032 [viral process] GO:0017134 [fibroblast growth factor binding] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019899 [enzyme binding] GO:0022627 [cytosolic small ribosomal subunit] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0051347 [positive regulation of transferase activity] GO:0070062 [extracellular exosome] Show all	293 aa 31.3 kDa	No	0
RPS2-006 ENSP00000436865 ENST00000526522	E9PQD7 [Direct mapping] 40S ribosomal protein S2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] Show all	235 aa 25.2 kDa	No	0
RPS2-007 ENSP00000433034 ENST00000527302	E9PMM9 [Direct mapping] 40S ribosomal protein S2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	218 aa 23 kDa	No	0
RPS2-008 ENSP00000433170 ENST00000529806	E9PM36 [Direct mapping] 40S ribosomal protein S2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	209 aa 21.6 kDa	No	0
RPS2-013 ENSP00000436227 ENST00000533186	H0YEN5 [Direct mapping] 40S ribosomal protein S2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005737 [cytoplasm] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	195 aa 21.2 kDa	No	0
RPS2-015 ENSP00000460860 ENST00000526586	I3L404 [Direct mapping] 40S ribosomal protein S2 Show all	SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	155 aa 16.6 kDa	No	0
RPS2-017 ENSP00000436356 ENST00000530225	E9PPT0 [Direct mapping] 40S ribosomal protein S2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] GO:0015935 [small ribosomal subunit] Show all	197 aa 21 kDa	No	0
RPS2-018 ENSP00000454837 ENST00000563194	H3BNG3 [Direct mapping] 40S ribosomal protein S2 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003735 [structural constituent of ribosome] GO:0005840 [ribosome] GO:0006412 [translation] Show all	44 aa 5.1 kDa	No	0

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