Expression of DEF8 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DEF8
Gene description	Differentially expressed in FDCP 8 homolog (mouse)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification.
Reliability score	Approved based on 1 antibody. HPA041745
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA041745

GENE INFORMATION
Gene name	DEF8 (HGNC Symbol)
Synonyms	FLJ20186
Description	Differentially expressed in FDCP 8 homolog (mouse) (HGNC Symbol)
Entrez gene summary
Chromosome	16
Cytoband	q24.3
Chromosome location (bp)	89947925 - 89968060
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000140995 (version 83.38)
Entrez gene	54849
UniProt	Q6ZN54 (UniProt - Evidence at protein level)
neXtProt	NX_Q6ZN54
Antibodypedia	DEF8 antibodies

PROTEIN BROWSER

DEF8-001	DEF8-002	DEF8-003	DEF8-004	DEF8-005	DEF8-006	DEF8-007	DEF8-009	DEF8-012	DEF8-013	DEF8-014	DEF8-015	DEF8-016	DEF8-017	DEF8-018	DEF8-022	DEF8-026	DEF8-201	DEF8-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEF8-001 ENSP00000268676 ENST00000268676	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	512 aa 58.7 kDa	No	0
DEF8-002 ENSP00000412784 ENST00000418391	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	197 aa 23 kDa	No	0
DEF8-003 ENSP00000458019 ENST00000563594	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	451 aa 52.3 kDa	No	0
DEF8-004 ENSP00000456501 ENST00000569453	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	451 aa 52.3 kDa	No	0
DEF8-005 ENSP00000457627 ENST00000563795	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	434 aa 50.2 kDa	No	0
DEF8-006 ENSP00000456095 ENST00000567874	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	391 aa 45.4 kDa	No	0
DEF8-007 ENSP00000456799 ENST00000570182	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	441 aa 51.2 kDa	No	0
DEF8-009 ENSP00000457072 ENST00000567999	H3BT87 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		150 aa 17.5 kDa	No	0
DEF8-012 ENSP00000456954 ENST00000566079	H3BT01 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		136 aa 15.4 kDa	No	0
DEF8-013 ENSP00000455783 ENST00000566820	H3BQH5 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		127 aa 14.8 kDa	No	0
DEF8-014 ENSP00000457309 ENST00000561741	H3BTS7 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		186 aa 21.1 kDa	Yes	0
DEF8-015 ENSP00000455987 ENST00000562986	H3BQX9 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	125 aa 14.7 kDa	No	0
DEF8-016 ENSP00000456157 ENST00000567884	H3BRA7 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		106 aa 12.1 kDa	No	0
DEF8-017 ENSP00000454478 ENST00000569061	H3BMP4 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		134 aa 15.5 kDa	No	0
DEF8-018 ENSP00000454534 ENST00000562578	H3BMT5 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] Show all	177 aa 20.4 kDa	No	0
DEF8-022 ENSP00000456706 ENST00000561959	H3BSH6 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008270 [zinc ion binding] Show all	176 aa 20.1 kDa	No	0
DEF8-026 ENSP00000454930 ENST00000564836	H3BNN0 [Direct mapping] Differentially-expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.5 kDa	No	0
DEF8-201 ENSP00000480073 ENST00000610455	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	197 aa 23 kDa	No	0
DEF8-202 ENSP00000482524 ENST00000617948	Q6ZN54 [Direct mapping] Differentially expressed in FDCP 8 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0008270 [zinc ion binding] GO:0035556 [intracellular signal transduction] Show all	451 aa 52.3 kDa	No	0