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Most of the malignant tissues displayed moderate cytoplasmic and membranous positivity. A few cases of ovarian and colorectal cancers were strongly stained. Malignant carcinoids, gliomas and lymphomas exhibited weak to moderate cytoplasmic staining.
Malignant tissues showed weak to moderate granular cytoplasmic staining. A single case each of papillary adenocarcinoma of thyroid, squamous cell carcinoma of cervix, malignant melanoma, colorectal and ovarian cancers displayed strong positivity. Malignant gliomas, malignant lymphomas, renal and testis cancers were negative.
GENE INFORMATION
Gene name
GAS8 (HGNC Symbol)
Synonyms
DRC4, GAS11
Description
Growth arrest-specific 8 (HGNC Symbol)
Entrez gene summary
This gene includes 11 exons spanning 25 kb and maps to a region of chromosome 16 that is sometimes deleted in breast and prostrate cancer. The second intron contains an apparently intronless gene, C16orf3, that is transcribed in the opposite orientation. This gene is a putative tumor suppressor gene. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]