Expression of MED9 in cancer - Summary - The Human Protein Atlas

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MED9

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MED9
Gene description	Mediator complex subunit 9
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA056415
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and pancreatic cancer (favourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA056415

GENE INFORMATION
Gene name	MED9 (HGNC Symbol)
Synonyms	FLJ10193, MED25
Description	Mediator complex subunit 9 (HGNC Symbol)
Entrez gene summary	The multiprotein Mediator complex is a coactivator required for activation of RNA polymerase II transcription by DNA bound transcription factors. The protein encoded by this gene is thought to be a subunit of the Mediator complex. This gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	17476986 - 17493226
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141026 (version 83.38)
Entrez gene	55090
UniProt	Q9NWA0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NWA0
Antibodypedia	MED9 antibodies

PROTEIN BROWSER

MED9-001	MED9-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MED9-001 ENSP00000268711 ENST00000268711	Q9NWA0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 9 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001104 [RNA polymerase II transcription cofactor activity] GO:0005515 [protein binding] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0016592 [mediator complex] Show all	146 aa 16.4 kDa	No	0
MED9-002 ENSP00000463031 ENST00000580462	J3KTK5 [Direct mapping] Mediator complex subunit 9; Mediator of RNA polymerase II transcription subunit 9 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		82 aa 8.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.