Expression of NCOR1 in cancer - Summary - The Human Protein Atlas

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NCOR1

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NCOR1
Gene description	Nuclear receptor corepressor 1
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	14
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA050288 , HPA051168 , CAB072830
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA050288	HPA051168	CAB072830

GENE INFORMATION
Gene name	NCOR1 (HGNC Symbol)
Synonyms	hCIT529I10, hN-CoR, KIAA1047, MGC104216, N-CoR, PPP1R109, TRAC1
Description	Nuclear receptor corepressor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]
Chromosome	17
Cytoband
Chromosome location (bp)	16029157 - 16218185
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141027 (version 83.38)
Entrez gene	9611
UniProt	O75376 (UniProt - Evidence at protein level)
neXtProt	NX_O75376
Antibodypedia	NCOR1 antibodies

PROTEIN BROWSER

NCOR1-001	NCOR1-002	NCOR1-003	NCOR1-006	NCOR1-007	NCOR1-009	NCOR1-012	NCOR1-015	NCOR1-017	NCOR1-018	NCOR1-025	NCOR1-026	NCOR1-029	NCOR1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCOR1-001 ENSP00000268712 ENST00000268712	O75376 [Direct mapping] Nuclear receptor corepressor 1 A0A024RD47 [Target identity:100%; Query identity:100%] Nuclear receptor co-repressor 1, isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001012 [RNA polymerase II regulatory region DNA binding] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0002155 [regulation of thyroid hormone mediated signaling pathway] GO:0002361 [CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation] GO:0003677 [DNA binding] GO:0003682 [chromatin binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005667 [transcription factor complex] GO:0005737 [cytoplasm] GO:0005876 [spindle microtubule] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007519 [skeletal muscle tissue development] GO:0007595 [lactation] GO:0007623 [circadian rhythm] GO:0008284 [positive regulation of cell proliferation] GO:0010467 [gene expression] GO:0010629 [negative regulation of gene expression] GO:0014067 [negative regulation of phosphatidylinositol 3-kinase signaling] GO:0016020 [membrane] GO:0016568 [chromatin modification] GO:0016580 [Sin3 complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0019904 [protein domain specific binding] GO:0021549 [cerebellum development] GO:0021794 [thalamus development] GO:0030331 [estrogen receptor binding] GO:0031065 [positive regulation of histone deacetylation] GO:0032922 [circadian regulation of gene expression] GO:0035033 [histone deacetylase regulator activity] GO:0035257 [nuclear hormone receptor binding] GO:0040014 [regulation of multicellular organism growth] GO:0042632 [cholesterol homeostasis] GO:0042826 [histone deacetylase binding] GO:0042974 [retinoic acid receptor binding] GO:0042975 [peroxisome proliferator activated receptor binding] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0046329 [negative regulation of JNK cascade] GO:0046965 [retinoid X receptor binding] GO:0046966 [thyroid hormone receptor binding] GO:0048471 [perinuclear region of cytoplasm] GO:0051225 [spindle assembly] GO:0060318 [definitive erythrocyte differentiation] GO:0072362 [regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter] GO:0072368 [regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter] GO:1904017 [cellular response to Thyroglobulin triiodothyronine] GO:2000191 [regulation of fatty acid transport] Show all	2440 aa 270.2 kDa	No	0
NCOR1-002 ENSP00000387727 ENST00000436828	E7EVU5 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	537 aa 63 kDa	No	0
NCOR1-003 ENSP00000379192 ENST00000395851	O75376 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005876 [spindle microtubule] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007623 [circadian rhythm] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016568 [chromatin modification] GO:0016580 [Sin3 complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0035257 [nuclear hormone receptor binding] GO:0042826 [histone deacetylase binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046329 [negative regulation of JNK cascade] GO:0046966 [thyroid hormone receptor binding] GO:0051225 [spindle assembly] GO:0072362 [regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter] GO:0072368 [regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter] GO:2000191 [regulation of fatty acid transport] Show all	2337 aa 258.6 kDa	No	0
NCOR1-006 ENSP00000389839 ENST00000436068	H0Y459 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		92 aa 9.9 kDa	No	0
NCOR1-007 ENSP00000379189 ENST00000395848	O75376 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000118 [histone deacetylase complex] GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0001102 [RNA polymerase II activating transcription factor binding] GO:0003677 [DNA binding] GO:0003714 [transcription corepressor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005876 [spindle microtubule] GO:0006325 [chromatin organization] GO:0006351 [transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007623 [circadian rhythm] GO:0010467 [gene expression] GO:0016020 [membrane] GO:0016568 [chromatin modification] GO:0016580 [Sin3 complex] GO:0016922 [ligand-dependent nuclear receptor binding] GO:0017053 [transcriptional repressor complex] GO:0035257 [nuclear hormone receptor binding] GO:0042826 [histone deacetylase binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046329 [negative regulation of JNK cascade] GO:0046966 [thyroid hormone receptor binding] GO:0051225 [spindle assembly] GO:0072362 [regulation of glycolytic process by negative regulation of transcription from RNA polymerase II promoter] GO:0072368 [regulation of lipid transport by negative regulation of transcription from RNA polymerase II promoter] GO:2000191 [regulation of fatty acid transport] Show all	914 aa 103.9 kDa	No	0
NCOR1-009 ENSP00000407998 ENST00000411510	E7EW50 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	545 aa 64 kDa	No	0
NCOR1-012 ENSP00000410784 ENST00000430577	C9JAP0 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		125 aa 14.4 kDa	No	0
NCOR1-015 ENSP00000463169 ENST00000580554	J3QKP0 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		217 aa 23.5 kDa	No	0
NCOR1-017 ENSP00000462308 ENST00000582357	J3KS51 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	546 aa 64.1 kDa	No	0
NCOR1-018 ENSP00000379190 ENST00000395849	E7EVK1 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		1071 aa 116.3 kDa	No	0
NCOR1-025 ENSP00000462281 ENST00000579606	J3KS29 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		184 aa 20 kDa	No	0
NCOR1-026 ENSP00000461959 ENST00000579573	J3KRE4 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		183 aa 19.3 kDa	No	0
NCOR1-029 ENSP00000474008 ENST00000603989	S4R380 [Direct mapping] Nuclear receptor corepressor 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.5 kDa	No	0
NCOR1-201 ENSP00000379198 ENST00000395857	A0A088AWL3 [Direct mapping] Nuclear receptor corepressor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Nonsense Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005634 [nucleus] Show all	2343 aa 259 kDa	No	0

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