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NOB1

GENERAL INFORMATION

Gene name

 NOB1

Gene description

 NIN1/RPN12 binding protein 1 homolog

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in all tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA049430
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable) and liver cancer (unfavourable).
Head and neck cancer p<0.001
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA049430

GENE INFORMATION

Gene name

 NOB1 (HGNC Symbol)

Synonyms

 ART-4, MST158, NOB1P, PSMD8BP1

Description

 NIN1/RPN12 binding protein 1 homolog (HGNC Symbol)

Entrez gene summary

 In yeast, over 200 protein and RNA cofactors are required for ribosome assembly, and these are generally conserved in eukaryotes. These factors orchestrate modification and cleavage of the initial 35S precursor rRNA transcript into the mature 18S, 5.8S, and 25S rRNAs, folding of the rRNA, and binding of ribosomal proteins and 5S RNA. Nob1 is involved in pre-rRNA processing. In a late cytoplasmic processing step, Nob1 cleaves a 20S rRNA intermediate at cleavage site D to produce the mature 18S rRNA (Lamanna and Karbstein, 2009 [PubMed 19706509]).[supplied by OMIM, Nov 2010]

Chromosome

 16

Cytoband

 q22.1

Chromosome location (bp)

 69741867 - 69754940

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141101 (version 83.38)

Entrez gene

 28987

UniProt

 Q9ULX3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULX3

Antibodypedia

 NOB1 antibodies

PROTEIN BROWSER
NOB1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NOB1-001
ENSP00000268802
ENST00000268802
Q9ULX3 [Direct mapping]
RNA-binding protein NOB1
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   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000469 [cleavage involved in rRNA processing]
GO:0004521 [endoribonuclease activity]
GO:0005634 [nucleus]
GO:0007601 [visual perception]
GO:0030490 [maturation of SSU-rRNA]
GO:0030688 [preribosome, small subunit precursor]
GO:0042274 [ribosomal small subunit biogenesis]
GO:0046872 [metal ion binding]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
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 412 aa
46.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.