Expression of PRPSAP2 in cancer - Summary

GENERAL INFORMATION
Gene name	PRPSAP2
Gene description	Phosphoribosyl pyrophosphate synthetase-associated protein 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	19
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA021881
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA021881

GENE INFORMATION
Gene name	PRPSAP2 (HGNC Symbol)
Synonyms	PAP41
Description	Phosphoribosyl pyrophosphate synthetase-associated protein 2 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that associates with the enzyme phosphoribosylpyrophosphate synthetase (PRS). PRS catalyzes the formation of phosphoribosylpyrophosphate which is a substrate for synthesis of purine and pyrimidine nucleotides, histidine, tryptophan and NAD. PRS exists as a complex with two catalytic subunits and two associated subunits. This gene encodes a non-catalytic associated subunit of PRS. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Chromosome	17
Cytoband	p11.2
Chromosome location (bp)	18840085 - 18931287
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141127 (version 83.38)
Entrez gene	5636
UniProt	O60256 (UniProt - Evidence at protein level)
neXtProt	NX_O60256
Antibodypedia	PRPSAP2 antibodies

PROTEIN BROWSER

PRPSAP2-001	PRPSAP2-004	PRPSAP2-005	PRPSAP2-008	PRPSAP2-009	PRPSAP2-010	PRPSAP2-012	PRPSAP2-013	PRPSAP2-014	PRPSAP2-015	PRPSAP2-017	PRPSAP2-019	PRPSAP2-022	PRPSAP2-023	PRPSAP2-024	PRPSAP2-028	PRPSAP2-201	PRPSAP2-202	PRPSAP2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRPSAP2-001 ENSP00000460967 ENST00000570450	C9JDU5 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	176 aa 19.9 kDa	No	0
PRPSAP2-004 ENSP00000416964 ENST00000414602	C9JJS3 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	194 aa 21.8 kDa	No	0
PRPSAP2-005 ENSP00000268835 ENST00000268835	O60256 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 A0A024QYY3 [Target identity:100%; Query identity:100%] Phosphoribosyl pyrophosphate synthetase-associated protein 2, isoform CRA_a Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0002189 [ribose phosphate diphosphokinase complex] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0004857 [enzyme inhibitor activity] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0043086 [negative regulation of catalytic activity] GO:0043234 [protein complex] GO:0060348 [bone development] Show all	369 aa 40.9 kDa	No	0
PRPSAP2-008 ENSP00000399625 ENST00000432893	E7EPA1 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	268 aa 29.6 kDa	No	0
PRPSAP2-009 ENSP00000402612 ENST00000412418	E7EPA1 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	268 aa 29.6 kDa	No	0
PRPSAP2-010 ENSP00000395127 ENST00000441887	C9JDH0 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		140 aa 15.6 kDa	No	0
PRPSAP2-012 ENSP00000415446 ENST00000419284	C9JDU5 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	176 aa 19.9 kDa	No	0
PRPSAP2-013 ENSP00000401144 ENST00000422237	C9K0K7 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	244 aa 27.1 kDa	No	0
PRPSAP2-014 ENSP00000461241 ENST00000460724	I3L4G9 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	143 aa 15.7 kDa	No	0
PRPSAP2-015 ENSP00000392536 ENST00000419071	O60256 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0004857 [enzyme inhibitor activity] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0043086 [negative regulation of catalytic activity] Show all	329 aa 36.3 kDa	No	0
PRPSAP2-017 ENSP00000439129 ENST00000542013	O60256 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0004857 [enzyme inhibitor activity] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0043086 [negative regulation of catalytic activity] Show all	320 aa 35.5 kDa	No	0
PRPSAP2-019 ENSP00000460138 ENST00000574522	I3L331 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		93 aa 10.5 kDa	No	0
PRPSAP2-022 ENSP00000458600 ENST00000576355	I3L164 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		104 aa 11.6 kDa	No	0
PRPSAP2-023 ENSP00000459441 ENST00000575102	I3L275 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		22 aa 2.4 kDa	No	0
PRPSAP2-024 ENSP00000460324 ENST00000575228	I3L3B8 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		57 aa 6.3 kDa	No	0
PRPSAP2-028 ENSP00000458301 ENST00000574451	I3L0S1 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0009165 [nucleotide biosynthetic process] Show all	260 aa 28.6 kDa	No	0
PRPSAP2-201 ENSP00000443967 ENST00000536323	O60256 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0004857 [enzyme inhibitor activity] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0043086 [negative regulation of catalytic activity] Show all	283 aa 31.3 kDa	No	0
PRPSAP2-202 ENSP00000481322 ENST00000610773	O60256 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000287 [magnesium ion binding] GO:0004749 [ribose phosphate diphosphokinase activity] GO:0004857 [enzyme inhibitor activity] GO:0006139 [nucleobase-containing compound metabolic process] GO:0009165 [nucleotide biosynthetic process] GO:0043086 [negative regulation of catalytic activity] Show all	283 aa 31.3 kDa	No	0
PRPSAP2-203 ENSP00000487485 ENST00000628609	I3L1T1 [Direct mapping] Phosphoribosyl pyrophosphate synthase-associated protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		47 aa 5.2 kDa	No	0