Expression of UNC45B in cancer - Summary - The Human Protein Atlas

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UNC45B

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	UNC45B
Gene description	Unc-45 myosin chaperone B
Protein class	Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (head and neck cancer, testis cancer)
HPA (cell line):	Cell line enriched (BEWO)
HPA (normal tissue):	Group enriched (heart muscle, skeletal muscle)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification. Antibody staining not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA017861
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (head and neck cancer, testis cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA017861

GENE INFORMATION
Gene name	UNC45B (HGNC Symbol)
Synonyms	CMYA4, UNC45
Description	Unc-45 myosin chaperone B (HGNC Symbol)
Entrez gene summary	This gene encodes a co-chaperone required for folding and accumulation of type II myosins. The protein consists of three tetratricopeptide repeat motifs at the N-terminus that form a complex with heat shock protein 90, a central region of unknown function that is conserved in all Unc-45 proteins, and a C-terminal Unc-45/Cro1/She4 domain. The protein is expressed at high levels in striated muscle, where its muscle myosin chaperone activity is dependent on heat shock protein 90 acting as a co-chaperone. A missense mutation in this gene has been associated with cataract development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Chromosome	17
Cytoband	q12
Chromosome location (bp)	35147817 - 35189345
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141161 (version 83.38)
Entrez gene	146862
UniProt	Q8IWX7 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IWX7
Antibodypedia	UNC45B antibodies

PROTEIN BROWSER

UNC45B-001	UNC45B-002	UNC45B-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
UNC45B-001 ENSP00000268876 ENST00000268876	Q8IWX7 [Direct mapping] Protein unc-45 homolog B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002088 [lens development in camera-type eye] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007517 [muscle organ development] GO:0030154 [cell differentiation] GO:0051879 [Hsp90 protein binding] GO:0061077 [chaperone-mediated protein folding] Show all	931 aa 103.7 kDa	No	0
UNC45B-002 ENSP00000378071 ENST00000394570	Q8IWX7 [Direct mapping] Protein unc-45 homolog B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002088 [lens development in camera-type eye] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007517 [muscle organ development] GO:0030154 [cell differentiation] Show all	929 aa 103.6 kDa	No	0
UNC45B-003 ENSP00000468335 ENST00000591048	Q8IWX7 [Direct mapping] Protein unc-45 homolog B Show all	Predicted intracellular proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0002088 [lens development in camera-type eye] GO:0005488 [binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0007517 [muscle organ development] GO:0030154 [cell differentiation] Show all	850 aa 94.8 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.