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PCTP

GENERAL INFORMATION

Gene name

 PCTP

Gene description

 Phosphatidylcholine transfer protein

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA022979
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (unfavourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA022979

GENE INFORMATION

Gene name

 PCTP (HGNC Symbol)

Synonyms

 STARD2

Description

 Phosphatidylcholine transfer protein (HGNC Symbol)

Entrez gene summary

Chromosome

 17

Cytoband

 q22

Chromosome location (bp)

 55750979 - 55842830

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000141179 (version 83.38)

Entrez gene

 58488

UniProt

 Q9UKL6 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UKL6

Antibodypedia

 PCTP antibodies

PROTEIN BROWSER
PCTP-001
PCTP-004
PCTP-006
PCTP-008
PCTP-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PCTP-001
ENSP00000268896
ENST00000268896
Q9UKL6 [Direct mapping]
Phosphatidylcholine transfer protein
Q549N3 [Target identity:100%; Query identity:100%]
Phosphatidylcholine transfer protein; Phosphatidylcholine transfer protein, isoform CRA_c; cDNA, FLJ95327, highly similar to Homo sapiens phosphatidylcholine transfer protein (PCTP), mRNA
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006869 [lipid transport]
GO:0008203 [cholesterol metabolic process]
GO:0008289 [lipid binding]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0015914 [phospholipid transport]
GO:0031210 [phosphatidylcholine binding]
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 214 aa
24.8 kDa 		No 0
PCTP-004
ENSP00000325181
ENST00000325214
Q9UKL6 [Direct mapping]
Phosphatidylcholine transfer protein
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005829 [cytosol]
GO:0006869 [lipid transport]
GO:0008289 [lipid binding]
GO:0008525 [phosphatidylcholine transporter activity]
GO:0015914 [phospholipid transport]
GO:0031210 [phosphatidylcholine binding]
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 142 aa
16.8 kDa 		No 0
PCTP-006
ENSP00000459793
ENST00000576183
I3L2M9 [Direct mapping]
Phosphatidylcholine transfer protein; Phosphatidylcholine transfer protein, isoform CRA_b
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008289 [lipid binding]
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 203 aa
23.4 kDa 		No 0
PCTP-008
ENSP00000460437
ENST00000573500
I3L3H0 [Direct mapping]
Phosphatidylcholine transfer protein; Phosphatidylcholine transfer protein, isoform CRA_a
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008289 [lipid binding]
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 219 aa
25.5 kDa 		No 0
PCTP-010
ENSP00000461676
ENST00000572536
I3L4Z8 [Direct mapping]
Phosphatidylcholine transfer protein
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0008289 [lipid binding]
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 146 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.