Cell atlas - TOB1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	TOB1
Gene description	Transducer of ERBB2, 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved)
Additional location	In addition localized to the Vesicles (approved)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA047839
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to vesicles.

Main location

Nucleoplasm (approved)

Additional location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA047839	A549	Nucleoplasm
HPA047839	A549	Vesicles
HPA047839	MCF7	Nucleoplasm
HPA047839	MCF7	Vesicles
HPA047839	U-2 OS	Nucleoplasm
HPA047839	U-2 OS	Vesicles

MOUSE CELLS

Main location

Nucleoplasm

Additional location

Vesicles

Mouse gene

ENSMUSG00000037573 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA047839	NIH 3T3	Nucleoplasm
	HPA047839	NIH 3T3	Vesicles

GENE INFORMATION
Gene name	TOB1 (HGNC Symbol)
Synonyms	TOB, TROB, TROB1
Description	Transducer of ERBB2, 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Chromosome	17
Cytoband	q21.33
Chromosome location (bp)	50862223 - 50867978
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000141232 (version 83.38)
Entrez gene	10140
UniProt	P50616 (UniProt - Evidence at protein level)
neXtProt	NX_P50616
Antibodypedia	TOB1 antibodies

PROTEIN BROWSER

TOB1-001	TOB1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOB1-001 ENSP00000427695 ENST00000499247	P50616 [Direct mapping] Protein Tob1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003714 [transcription corepressor activity] GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007184 [SMAD protein import into nucleus] GO:0008285 [negative regulation of cell proliferation] GO:0009967 [positive regulation of signal transduction] GO:0017148 [negative regulation of translation] GO:0030014 [CCR4-NOT complex] GO:0030514 [negative regulation of BMP signaling pathway] GO:0030971 [receptor tyrosine kinase binding] GO:0045668 [negative regulation of osteoblast differentiation] GO:0046332 [SMAD binding] GO:0060212 [negative regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:1903507 [negative regulation of nucleic acid-templated transcription] Show all	345 aa 38.2 kDa	No	0
TOB1-002 ENSP00000268957 ENST00000268957	P50616 [Direct mapping] Protein Tob1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0008285 [negative regulation of cell proliferation] GO:0009967 [positive regulation of signal transduction] GO:0017148 [negative regulation of translation] GO:0030014 [CCR4-NOT complex] GO:0030971 [receptor tyrosine kinase binding] GO:0060212 [negative regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:0060213 [positive regulation of nuclear-transcribed mRNA poly(A) tail shortening] GO:1900153 [positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] Show all	345 aa 38.2 kDa	No	0